ATS 2024 Final Program

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102

SUNDAY • MAYs 19

• provide data to better diagnose post-TB lung disease and care for TB survivors This symposium will provide a review of recent advances in the field of post-TB lung disease, from the burden and epidemiology to the clinical overlap with diseases such as NTM pulmonary disease, COPD, bronchiectasis, and fibrotic lung diseases to the pathogenesis, biomarkers and potential therapeutics to improve long-term outcomes among TB survivors. 2:15 Post-TB Lung Disease: Assessing the Global Burden 2:30 Patterns of Post-TB Lung Disease: Overlap with COPD, Bronchiectasis, and Fibrotic Lung Diseases 2:45 Post-TB Pathogenesis: Matrix Destruction and Remodeling 3:00 Circulating Biomarkers and Potential Therapeutics for Post-TB Lung Disease 3:15 Patient-Reported Outcomes After TB and Caring for TB Survivors 3:30 Round Table Q&A A89 MECHANICAL FORCES IN LUNG DISEASE Assemblies on Respiratory Structure and Function; Respiratory Cell and Molecular Biology; PhD; Basic and Translational Scientist Working Group 2:15 p.m. - 3:45 p.m. Marriott Marquis San Diego Marina Pacific Ballroom 21-22 (Ground Floor, North Tower) Target Audience Scientists and Physician Scientists interested in understanding how mechanical forces in the lung alter the lung environment in health and disease. Objectives At the conclusion of this session, the participant will be able to: • identify the gaps in our knowledge about the functional impact of mechanical forces in lung disease • identify the importance of researching the functional impact of mechanical forces to elucidate its role in lung pathology. These studies are integral for the development of targeting treatment strategies BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

• identifys the current experimental methods for examining mechanotransduction with the goal of spurring more research and collaborations in this field Multiple endothelial, epithelial and mesenchymal mechanotransducers have been identified, including those in cell adhesion protein complexes, primary cilia, mechanically gated ion channels and integrin-related cell-ECM interactions. In addition to their role in normal respiration, physical forces are also integral for the development and progression of acute and chronic lung diseases. The experts presenting at this symposium will provide insight into the contribution of biophysical forces to the normal function of the lung as well as how the perturbations in these forces both drive and reinforce lung disease. In addition, the presenters will highlight novel cutting-edge molecular techniques to study these forces in vitro and in vivo. 2:15 The Role of Matrix Stiffness on the Regulation of the Fibrotic Response 2:30 Fibroblast-Extracellular Matrix Interactions and Modulation of the Mechanical and Biochemical Microenvironment 2:45 Microenvironmental Cues at the Alveolar Capillary Barrier in Lung Injury 3:00 Microenvironmental Mechanics and Alveolar Epithelial Cells Synergistically Drive Fibroblast Activation in 3D Lung Models 3:15 Stiffness, Contraction, and Stretch-Responsiveness of Human Precision Cut Lung Slices 3:30 Crystal Ribcage: A Platform To Probe Lung Mechanobiology

BASIC SCIENTIFIC SYMPOSIUM

A90 METABOLITE INTERACTIONS IN HEALTH AND DISEASE: UNVEILING THE MUTUAL FEEDING BETWEEN HOST AND MICROBIOTA Assemblies on Allergy, Immunology and Inflammation; Pulmonary Infections and Tuberculosis; Respiratory Cell and Molecular Biology 2:15 p.m. - 3:45 p.m. Marriott Marquis San Diego Marina Grand Ballroom 11-13 (Lobby Level, North Tower)

ATS 2024 Conference Program • San Diego, CA