ATS 2024 Final Program

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SUNDAY • MAY 19

109

211 A Novel Transcriptomics-based Method for Quantifying Circulating Endothelial Cells for Pathogenesis and Prognosis in Respiratory Failure and Acute Respiratory Distress Syndrome 212 Red Cell Aggregation Size and Velocity Predicts the Presence and Rate of Recovery of Renal Failure in the Critically Ill Septic Patient: A Phenomenon of Mechanical Damage to the Microvascular Endothelium 213 Extracellular Vesicles From In Vitro Models of Bacterial-induced Acute Lung Injury Induce Endothelial Dysfunction in Naïve Pulmonary Endothelial Cells 214 Validation of Estrogen-responsive Tissue Inhibitor of Metalloproteinases-1 as a Sex-specific Biomarker for Acute Lung Injury 215 The Melanocortin System Attenuates Inflammation During Sepsis 216 Association of Plasma Histone 3.1 With Disease Severity in Pediatric Severe Acute COVID-19 and Multisystem Inflammatory Syndrome in Children 217 Admission Plasma Nuclear DNA Concentration Is Associated With ARDS in Critically Ill Patients 218 Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Failure Increases Plasma Levels of Citrullinated Histone H3, A Specific Marker of Neutrophil Extracellular Traps 219 Genomics and Machine Learning in the ICU: Defining Transcription Factor Activity Endotypes Associated With COVID-19 ARDS Severity 220 Supervised Multi-Omics Integration Identifies Differential Biomarkers of COVID Versus Non-COVID Acute Respiratory Distress Syndrome 221 Deep Phenotyping of Permeability Edema in COVID-19 Acute Respiratory Distress Syndrome (ARDS) 222 Inhalation of Nicotinamide Riboside Improved Metabolomic and Transcriptomic Bioenergetic Signatures in a Murine Sepsis Model 223 In-vivo and Ex-vivo Analysis of Tissue S-nitrosothiols in Pediatric Sepsis 224 Impact of Extended Lung Protection During Mechanical Ventilation on Lung Recovery in Patients With COVID-19 ARDS: A Phase II Randomized Controlled Trial 225 Lung Mechanics May Mediate Pro-fibrotic Signaling in Mechanically Ventilated Patients With ARDS

BASIC • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION

A103 DYSREGULATED PATHWAYS IN SEPSIS AND LUNG INJURY: SEARCHING FOR TREATABLE TRAITS 2:15 p.m. - 4:15 p.m.

San Diego Convention Center Room 1A-B (Upper Level)

Poster Viewing

2:15-3:00

Discussion 3:00-4:15 201 Distinct Neutrophil Phenotypes in Sepsis Patients and Associations With Disease Severity, Comorbidities, and Neutrophil Extracellular Traps (NETs) 202 A Population of Human Leukocyte Antigen - DR Isotype Expressing Low Density Granulocytes in Critical Illness 203 Increased Susceptibility to Pseudomonas Aeruginosa Pneumonia in Overventilated Lungs Is Caused by Airspace Acidification Via NHE1 204 CD40 Costimulatory Inhibition Modulates Immune Inflammation in Human Septic Peripheral Blood Mononuclear Cells 205 Metabolic Adaptation and Remodeling of the T Cell Compartment in Critical Illness and Severe Sepsis 206 Alveolar Th2 Cytokine Upregulation in Patients With Acute Respiratory Distress Syndrome (ARDS) and Non-dependent Consolidation 207 Circulating Heparan Sulfate Levels Correlate With Endothelial Dysfunction Biomarkers In Pediatric Acute Respiratory Distress Syndrome 208 ABO Modified VWF-ADAMTS13 Axis and STM Are Associated With ARDS Mortality in Critically Ill Patients With Sepsis 209 Elevated Circulating Cell-free Hemoglobin Drives Endothelial Glycocalyx Destruction and Inflammation in Sepsis 210 Alternative Pathway Complement Activation and Low Circulating Inhibitors Associate With Severity and Mortality in COVID-19 and Non-COVID Sepsis

ATS 2024 Conference Program • San Diego, CA

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