ATS 2024 Final Program

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203

MONDAY • MAY 20

3:27 Multiple T Cell Responses are Associated with Protection Against COVID-19 Disease and Lung Injury This session and the International Conference are supported by an independent medical educational grant from United Therapeutics Corporation. All CME sessions have been planned and implemented in accordance with the Accreditation Criteria of the Accreditation Council for Continuing Medical Education (ACCME ® ) and are free of the control of ineligible companies (formerly commercial interests). BASIC • BEHAVIORAL • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM B88 CUTTING EDGE VACCINE DEVELOPMENT FOR THE PULMONARY SUB-SPECIALTY COMMUNITY: VACCINE IMMUNOLOGY, RESEARCH, DEVELOPMENT, AND PRACTICE SOLUTIONS Assemblies on Pulmonary Infections and Tuberculosis; Pediatrics 2:15 p.m. - 3:45 p.m. Marriott Marquis San Diego Marina Grand Ballroom 11-13 (Lobby Level, North Tower) Target Audience ATS clinicians and members interested in vaccine development and implementation Objectives At the conclusion of this session, the participant will be able to: • improve patient health through promotion of vaccines and immunization • describe vaccine development as a potential tool to combat multi-drug resistant bacteria • understand the role current and developing vaccines play in improving respiratory health in adults Vaccines have had a significant impact on global health, reducing mortality from or even eradicating several devastating infections. However, vaccine-preventable illnesses remain a threat due to low vaccine coverage among adults, particularly important for those with chronic lung disease. The goal of this session is to outline challenges to and highlight strategies for improving global vaccination to combat a variety of respiratory illnesses and to emphasize the impact vaccines have on improving respiratory health and preventing respiratory morbidity. Multiple perspectives will be represented, including infectious diseases, behavioral , community engagement, health disparities, and public health policy.

BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

B87 IMMUNE MECHANISMS OF ACUTE LUNG INJURY FROM COVID AND BEYOND Assemblies on Allergy, Immunology and Inflammation; Respiratory Cell and Molecular Biology 2:15 p.m. - 3:45 p.m. Marriott Marquis San Diego Marina Pacific Ballroom 24-26 (Ground Floor, North Tower) Target Audience Physicians, scientists, lung injury researchers, critical care clinicians, pulmonologists Objectives At the conclusion of this session, the participant will be able to: • discuss the diverse populations of lung immune cells in health and injury • discuss the role of the immune cell transcriptome in ARDS • discuss potential therapeutic targets to treat pulmonary inflammation The innate and adaptive immune system play a significant role in the pathophysiology of lung injury. However, the precise mechanisms by which immune cells improve or exacerbate lung injury is poorly understood. The use of “omics” approaches in human cells and tissues has brought us closer to understanding these complex mechanisms of lung injury. Despite these advances, there remain several challenges in untangling the massive data sets generated from “omics”. In this symposium, leaders in the field of lung injury immune cell omics will share their approaches and lessons learned. By further understanding the patient-specific molecular mechanisms underlying immune-mediated lung injury, we can come closer to personalized therapies for acute lung tissue injury induced by inflammation. 2:15 Monocyte and Macrophage Diversity in the Healthy Lung 2:33 Alveolar Macrophage Transcriptome and ARDS Outcomes 2:51 Monocyte Gene Signatures in ARDS 3:09 An Omics Approach to Immune-Mediated Lung Injury from COVID-19

ATS 2024 Conference Program • San Diego, CA