ATS 2024 Final Program

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224

TUESDAY • MAY 21

10:20 Cross Talk Between the Epithelium and Mast Cells in the Context of Rhinovirus A Infection 10:40 Summary: The Influence of Rhinovirus Infection of the Airway Epithelium in Asthma

BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

C9 RHINOVIRUS INFECTION OF THE AIRWAY EPITHELIUM IN ASTHMA Assemblies on Allergy, Immunology and Inflammation; Respiratory Cell and Molecular Biology 9:15 a.m. - 10:45 a.m. San Diego Convention Center Room 24A-C (Upper Level) Target Audience Researchers and clinicians with an interest in understanding the effects of epithelial rhinovirus infection on the regulation of inflammation in asthma. Objectives At the conclusion of this session, the participant will be able to: • describe new findings about the regulation of inflammation relevant to asthma that occurs in response to rhinovirus infection • understand the regulation of inflammation through cell-to-cell interactions among epithelial cells and innate cells within the epithelium • gain insights into the prevention of rhinovirus mediated exacerbations of asthma Rhinovirus infection is common at asthma onset and during exacerbation and progression. Rhinovirus infection of the airway epithelium induces a strong type-1 immune response but leads clinically to features of type-2 (T2) inflammation in some individuals who are susceptible to or have asthma. Recent work in this area has revealed new insights into the alterations in antiviral immune responses in asthma, potential modulators of this response and connections between rhinovirus infection of the susceptible epithelium and the origin of the accentuated inflammatory response in asthma. 9:15 The Importance of Respiratory Viral Infection in the Pathogenesis of Asthma 9:20 Inflammatory Responses to Rhinovirus C Infection Involve Cross-Talk Between Epithelial Subsets 9:40 Differential Epigenetic Responses to Rhinovirus A at Asthma-Associated Loci in Bronchial Epithelial Cells 10:00 Antiviral Responses in Epithelial Cells from Individuals with Asthma

CLINICAL SCIENTIFIC SYMPOSIUM

C10 BEYOND TOBACCO: Non-SMOKING CAUSES OF COPD Assemblies on Environmental, Occupational and Population Health; Clinical Problems 9:15 a.m. - 10:45 a.m. Marriott Marquis San Diego Marina Grand Ballroom 11-13 (Lobby Level, North Tower) Target Audience Clinicians in pulmonary, pediatrics, infectious disease and occupational health fields, PhD scientists, respiratory health workers, environmental and urban health experts and members of environmental/ global health researchers and agencies. Objectives At the conclusion of this session, the participant will be able to: • increase awareness about Non-smoking related causes of COPD across the lifespan • review the evidence for specific Non-smoking related causes of COPD, including perinatal insults, post-infectious, occupational and environmental exposures • learn strategies to recognize and address Non-smoking related causes of COPD in clinical practice There is a growing need to address key contributors to COPD beyond tobacco use. This session highlights major drivers of Non-tobacco related COPD, and the impact of modifiable environmental exposures on COPD morbidity and mortality. Through this session, we will identify key knowledge gaps, highlight modifiable risk factors and provide practical guidance to address occupational and environmental drivers of COPD in clinical practice. 9:15 The State of the Science What Do We Know About Non-Smoking Related Causes of COPD? 9:30 Setting the Stage: the Role of In Utero and Early Life Exposures 9:45 Infectious Causes of COPD 10:00 Occupational COPD

ATS 2024 Conference Program • San Diego, CA