ATS 2024 Final Program

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226

TUESDAY • MAY 21

9:35 Supporting the Wellbeing of PhDs 9:45 Clinician Wellbeing - A Nursing Perspective 9:55 The Role of Sleep in Clinician Wellbeing 10:05 The Importance of Belonging: The Intersection of Wellbeing and Inclusion 10:15 Health Systems Solutions to Improve Provider Wellbeing 10:30 Question and Answer Period

9:35 Physiologic Endotypes Have Not Informed the Diagnosis of OSA 9:55 Physiologic Endotypes Have Not Informed Treatment Decisions for OSA 10:15 What is the Future Potential for Endotyping to Explain OSA Heterogeneity? 10:30 What are Alternative Pathways to Explain OSA Heterogeneity?

BASIC • TRANSLATIONAL MINI SYMPOSIUM

CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

C14 HARMONY IN HEALING: IMMUNE CELL CHOREGRAPHY OF LUNG INJURY AND REPAIR 9:15 a.m. - 11:15 a.m. Oral Presentations: 9:15 Impaired Complement Regulation Drives Chronic Lung Allograft Dysfunction After Lung Transplantation 9:27 MAIT Cells Protect Against Lung Injury 9:39 Reengaging CD8+ T Cells in Clearance of Senescent Cells in Lung Injury Repair 9:51 Antigenic Responses Are Hallmarks of Fibrotic Interstitial Lung Diseases Independent of Underlying Etiologies 10:03 Acute Lung Injury Induced Via Intra-tracheal Lipopolysaccharide Administration Results in Expansion of Lung Megakaryocytes 10:15 Treg Subset Kinetics and Effector Functions Are ALI Injury Specific 10:27 The Scavenger Receptor, LOX-1, Promotes Alveolar Macrophage Identity and Regulates Innate Immune Cell Activity to Limit Inflammatory Injury During Pneumonia 10:39 Hypomethylating Therapy Reduces Allograft Rejection in a Murine Lung Transplant Model 10:51 Decitabine Affects Lung Monocyte-macrophage Dynamics and Phenotype in Acute Lung Graft Rejection San Diego Convention Center Room 2 (Upper Level)

C13 REASSESSING THE VALUE OF PHYSIOLOGIC ENDOTYPES IN UNDERSTANDING OSA HETEROGENEITY Assemblies on Sleep and Respiratory Neurobiology 9:15 a.m. - 10:45 a.m. Target Audience Clinicians, researchers, and others interested in using pathophysiological insights to inform the care of patients with sleep-disordered breathing. Objectives At the conclusion of this session, the participant will be able to: • describe the OSA physiological endotypes and the evidence supporting the role of each in producing the OSA syndrome • review the robustness of evidence that physiologic endotypes can explain the heterogeneity in OSA and impact clinical decision-making on the diagnosis and treatment in patients seeking care for OSA • define next steps necessary using physiologic endotypes or other strategies to individualize the care of patients with OSA This session will critically evaluate the physiological endotype theory of obstructive sleep apnea pathogenesis, assess the robustness of findings resulting from this paradigm, and consider how to better utilize physiologic insights to advance an understanding of OSA heterogeneity and individualization of care. 9:15 Why the Basic Assumptions for OSA Physiologic Endotypes are Problematic Marriott Marquis San Diego Marina Grand Ballroom 8-9 (Lobby Level, North Tower)

ATS 2024 Conference Program • San Diego, CA