ATS 2024 Final Program

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234

TUESDAY • MAY 21

825 Advancing Diagnostic Precision of Emphysema in Chronic Obstructive Pulmonary Disease: Machine-Learning Classification Integrating Non-Invasive Biomarkers, Clinical Characteristics, and Pulmonary Function

509 Deconvolution of Human Pulmonary Artery Oxygen-sensing Cell Population in Health and Disease 510 BMP9-mediated ET-1 Transcription Requires Dual Activation of SMAD1/5/9 and SMAD2/3 511 XOR Activity in Scleroderma Associated-PAH 512 Circular RNA Profiling Identifies circ5078 as a BMPR2 -derived Regulator of Endothelial Translation 513 Hemin-induced Necrotic Pulmonary Artery Endothelial Dysfunction and Capillary Leak Is Regulated by Toll-like Receptor 4 514 HIF2A Activation Reduces Pulmonary Angiogenesis Methylation Status of Key Snai1-responsive Genes and Results in the Rescue of Pulmonary Hypertension-induced Right Ventricular Failure 516 Genetic Disruption of Protein C (PC) Binding to the Endothelial PC Receptor (EPCR) Selectively Impairs the Resolution of Acute Lung Injury in Mice 517 CYP1A1 Mediates Endothelial Dysfunction and Lung Injury Caused by Methicillin-resistant Staph Aureus (MRSA) 518 Epigenetic and Molecular Underpinnings of Preclinical and Clinical Group III Pulmonary Hypertension 519 Roles of CD26/DPP4 in Bleomycin-induced Pulmonary Hypertension in Mice 520 Hemoglobin-mediated Oxidation of Low-density Lipoprotein (oxLDL) Contributes to Lung Microvascular Endothelial Dysfunction Via Lectin-like Oxidized LDL Receptor 1 (LOX-1) 521 Shear Stress Increases Intracellular Calcium Concentration Via TRPV4 Channels in Human Lung Microvascular Endothelial Cells 522 Role of Pericyte Exosome-derived miRNAs in the Pathogenesis of Pulmonary Arterial Hypertension 523 Sex Differences in Pulmonary Arterial Hypertension Traced to Sphingosine-1-Phosphate Dynamics and Promotes Vascular Remodeling in PAH by Suppressing Wnt7a Production in Pulmonary Endothelial Cells 515 Snai1 Knockdown Induces Alterations in

BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION

C25 GASLAMP QUARTER: SHEDDING LIGHT ON VASCULAR PATHOGENIC MECHANISMS IN PAH 9:15 a.m. - 11:15 a.m. San Diego Convention Center Room 11A-B (Upper Level) Poster Viewing 9:15-10:00 Discussion 10:00-11:15 501 Combined Inhibition of Histone Deacetylases and Bromodomain Proteins Normalizes Gene Expression and Reverses Sugen/Hypoxia-induced Pulmonary Hypertension 502 SOX17 Deficiency Is Additive to High Shear Stress in Compromising Endothelial Integrity 503 RKER-012, A Novel Modified ActRIIB Ligand Trap, Reduced Pulmonary Vascular Pathology in a Rat Model of Pulmonary Arterial Hypertension Through Attenuation of TGFb Family Autocrine/Paracrine Signaling Within the Vasculature 504 Inverse Expression of SOX17 and RUNX1 in Pulmonary Hypertension 505 Endothelial RAB7 Deficiency Impairs Endothelial Metabolic and Proinflammatory Reprogramming of Vascular Fibroblasts in Pulmonary Hypertension 507 Role of Vascular and Mural Cells in a Hypoxia-Pneumonectomy Model of Flow-Induced Pulmonary Hypertension 508 PIN1 Is Increased in Endothelial Cells Derived From Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Function and Promotes Pulmonary Hypertension Via Potential Induction of Pulmonary Artery Smooth Muscle Cell Growth 506 Intracellular Complement Signaling Drives

ATS 2024 Conference Program • San Diego, CA