ATS 2024 Final Program

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SUNDAY • MAY 19

23

Target Audience Pulmonary scientists seeking to gain novel insights into how trained immunity, a durable form of innate immune cell reprogramming, may be modulated to maintain lung health or inhibit existing respiratory disease progression. Objectives At the conclusion of this session, the participant will be able to: • learn about the latest findings in the field of trained immunity and the evidence for its role in the host response to different infectious and inflammatory stimuli • understand how knowledge about trained immunity can be translated to address clinical challenges such as vaccine development and modulation of host immune responses to respiratory infections or pathological sterile inflammation • become aware of new strategies that have the potential to engage both innate and adaptive immune memory to favor enhanced protection against infectious and Non-infectious inflammatory diseases This symposium will provide the learner with a comprehensive introduction and overview of trained immunity in the context respiratory and systemic inflammatory diseases. The aim is to explore how functional reprogramming of innate immune cell subsets contributes to protective or pathological responses in the lung. The influence of trained immunity on systemic inflammatory diseases such as sepsis will also be discussed. Individual speakers will review the basic concepts and principles of innate immune memory, the roles played by epigenetics and altered cellular metabolism, as well as potential therapeutic approaches to modulate trained immunity. 9:15 Harnessing of Trained Immunity for Vaccine Development Against Mycobacterial and Viral Pathogens 9:33 Trained Immunity of Alveolar Macrophages Enhances Resistance to Bacterial Pneumonia 9:51 Trained Immunity in the Asthma Trajectory from Pregnancy to Childhood 10:09 Trained Immunity Exacerbates Diaphragm Pathology in Muscular Dystrophy 10:27 What’s Next? Perspectives on Future Scientific and Clinical Opportunities in Trained Immunity

• understand the current landscape of LLMs, including their design and existing applications • identify the future applications of LLMs in pulmonary and critical care clinical practice and scientific research • recognize the technical, social, and ethical concerns with LLMs and the need for guardrails to ensure safe and appropriate LLM use This scientific symposium presents a unique platform for the pulmonary and critical care communities to explore the transformative applications of Language Models (LLMs) in clinical practice and research. We will discuss the potential of LLMs in enhancing diagnosis, treatment, and patient care as well as opportunities for data analysis, clinical decision-making, and risk prediction in pulmonary and critical care medicine. The symposium will also address challenges such as manuscript authorship, data privacy, model interpretability, and integration of LLMs into existing healthcare systems. Speakers will offer their perspectives on the future of LLMs implementation in pulmonary and critical care fields. 9:15 Promise and Perils of LLMs in Pulmonary and Critical Care Medicine 9:30 Unleashing the Power of Language Models in Clinical Practice 9:45 The Natural Language of Clinical Education 10:00 FromManuscripts to Machines: Exploring the Changing Landscape of Peer Review with Language Models 10:15 The Quirks of Research Superpowers: Applying LLMs to Qualitative and Quantitative Methods 10:25 Panel Discussion

BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

A10 UNLOCKING THE THERAPEUTIC POTENTIAL OF TRAINED IMMUNITY IN RESPIRATORY DISEASES Assemblies on Allergy, Immunology and Inflammation; Critical Care; Environmental, Occupational and Population Health; Pulmonary Infections and Tuberculosis; Respiratory Cell and Molecular Biology; Respiratory Structure and Function 9:15 a.m. - 10:45 a.m. San Diego Convention Center Room 6D (Upper Level)

ATS 2024 Conference Program • San Diego, CA