ATS 2024 Final Program

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313

WEDNESDAY • MAY 22

Workshop working group within the BSHSR Assembly to address this gap. This symposium will present the committee’s findings, including a consensus definition, the essential elements necessary to conduct a time-limited trial, and the most pressing controversies and remaining questions about this approach. 8:15 Advocating for the Voice of Patients and Families in Time-Limited Trials 8:25 What We Know About the Current Use of Time-Limited Trials in Critical Care 8:35 I Know It When I See It? An Operational Definition of Time-Limited Trials in Critical Care 8:45 The Essential Elements for Conducting a Time-Limited Trial for Patients with Critical Illness 8:55 Rejoice in Tension: Rethinking Family Relationships Through Time-Limited Trials 9:05 Ethical Controversies in Time-Limited Trials: Pragmatic Solutions, Potential Hazards 9:15 The Challenge of Promoting Equity Through Time-Limited Trials 9:25 Putting Time-Limited Trials into Context 9:35 Q&A and Roundtable Discussion D6 WHAT CAUSES SARCOIDOSIS? Assemblies on Allergy, Immunology and Inflammation; Clinical Problems; Environmental, Occupational and Population Health; Respiratory Cell and Molecular Biology 8:15 a.m. - 9:45 a.m. San Diego Convention Center Room 29A-D (Upper Level) Target Audience Clinical and translational research pulmonologists, basic scientists and clinicians interested in host and environment interactions manifesting as interstitial lung disease and systemic inflammation. Objectives At the conclusion of this session, the participant will be able to: • apply new disease models and advanced technologies to advance understanding of sarcoidosis disease pathogenesis. BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

• describe new findings linking exposure to environmental antigens or autoantigens to sarcoidosis disease progression. • define new strategies to prevent sarcoidosis progression based on improved knowledge of the interactions between the host immune system and the environment that promote sarcoidosis disease progression. Despite decades of research the cause of sarcoidosis remains unclear, which is a source of frustration for healthcare providers, researchers and patients. Recent developments, including new disease models and research technologies, have provided novel insights into sarcoidosis disease pathogenesis, and will be featured in this session. These recent discoveries have important implications for guiding future mechanistic research and for developing more effective treatments and biomarkers for sarcoidosis. 8:15 Introduction, What is the Cause of Sarcoidosis? 8:20 A Patient's Perspective 8:25 The role of sarcoidosis-specific T-cell receptors and environmental antigens in sarcoidosis pathogenesis 8:45 Multi-omic signatures of sarcoidosis predicting sarcoidosis disease progression 9:05 Disrupted autophagy and impaired antigen clearance in sarcoidosis. 9:25 Altered intracellular pathogen responses promote sarcoidosis granuloma formation D7 WHERE CHILDREN LEARN AND BREATHE: THE IMPACT OF SCHOOL-BASED EXPOSURES ON CHILDHOOD RESPIRATORY HEALTH Assemblies on Pediatrics; Behavioral and Health Services Research; Environmental, Occupational and Population Health; Nursing 8:15 a.m. - 9:45 a.m. San Diego Convention Center Room 24A-C (Upper Level) Target Audience Our target audience is broad and includes clinical pediatric and adult pulmonologists, fellows and trainees, researchers, other BEHAVIORAL • CLINICAL SCIENTIFIC SYMPOSIUM

ATS 2024 • San Diego, CA