ATS 2024 Final Program

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315

WEDNESDAY • MAY 22

8:45 Current Biomarker Landscape for Early Diagnosis of PH and PVD: Integrating Cardiac MRI and Omics Data in the RV 9:00 Current Biomarker Landscape for Early Diagnosis of PH and PVD: Omics and Databases 9:15 Current Clinical Trial Landscape for PH and PVD in North America 9:30 Current Clinical Trial Landscape for PH and PVD in Europe This session and the International Conference are supported by independent medical educational grants from Johnson&Johnson, Merck&Co., Inc., andUnitedTherapeuticsCorporation. All CMEsessions have been planned and implemented in accordancewith the AccreditationCriteria of theAccreditationCouncil for ContinuingMedical Education (ACCME ® ) and are free of the control of ineligible companies (formerly commercial interests).

• describe new findings in the research literature including systems biology, computational biology and integrative biology of chronic lung disease. Emerging modalities to collect high-dimensional molecular profiles at single-cell and now with spatial resolution offer new potential to understand the cellular components of healthy lung tissue and its dysfunction in disease. They also present a profound opportunity to define molecular mechanisms responsible for patient heterogeneity, such as asthma endotypes. To realize these goals, it is necessary to develop and apply novel computational approaches and define new algorithms to extract biological meaning from these datasets. This session will bring together the leaders in computational of multi-omics data who are pioneering its application to high resolution lung systems biology. 8:15 Introduction 8:20 Determining Asthma Endotypes and Outcomes: Complementing Existing Clinical Practice with Modern Machine Learning 8:40 Cell Atlases as Roadmaps to Understand and Treat Disease 9:00 Cellular Cross-Talk Understanding Mechanisms Underlying Asthma Susceptibility 9:20 Unlocking Lung Health and Disease Using Novel Algorithms for Integrated Multi-Omics 9:40 Summary D10 TEAMWORK MAKES THE DREAM WORK: MULTIDISCIPLINARY APPROACHES FOR HIGH-QUALITY LUNG CANCER SCREENING Assembly on Thoracic Oncology 8:15 a.m. - 9:45 a.m. Marriott Marquis San Diego Marina Pacific Ballroom 18-19 (Ground Floor, North Tower) Target Audience The target audience includes pulmonologists and interventional pulmonologists, thoracic radiologists, thoracic surgeons, primary care providers, cancer epidemiologists, public health experts, and behavioral health and implementation scientists. CLINICAL SCIENTIFIC SYMPOSIUM

BASIC SCIENTIFIC SYMPOSIUM

D9 LINKING NOVEL MULTI-OMICS WITH MACHINE LEARNING TO UNLOCK LUNG PATHOPHYSIOLOGY Assemblies on Respiratory Structure and Function; Allergy, Immunology and Inflammation; Respiratory Cell and

Molecular Biology 8:15 a.m. - 9:45 a.m.

Marriott Marquis San Diego Marina Pacific Ballroom 24-26 (Ground Floor, North Tower)

Target Audience Basic and clinical scientists interested in how emerging methods such as spatial transcriptomics and single-cell RNA and ATAC sequencing can elucidate the integrative biology of the lung and the manifold causes of airway inflammation and asthma. Objectives At the conclusion of this session, the participant will be able to: • apply emerging ‘omics modalities to their own research questions and model systems, and integrate their current thinking more deeply with computational approaches and paradigms. • apply computational frameworks to a range of research questions in lung disease pathophysiology, understand the capabilities of machine learning approaches and how they can open up new areas of inquiry.

ATS 2024 • San Diego, CA