ATS 2024 Final Program

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337

WEDNESDAY • MAY 22

11:56 Not Just Apnea: Sleep Lab Optimization of NIV 12:13 Home Monitoring: Novel Strategies for NIV Optimization

BASIC • CLINICAL SCIENTIFIC SYMPOSIUM

D86 AMBULATORY CRITICAL CARE: A BENCH TO BEDSIDE UNDERSTANDING OF CHRONIC RESPIRATORY FAILURE Assemblies on Sleep and Respiratory Neurobiology; Clinical Problems 11:00 a.m. - 12:30 p.m. Target Audience Sleep, pulmonary and critical care clinicians who may care for patients on home ventilation. Outpatient and inpatient respiratory therapists. Scientists interested in the effects of CO2 on the body. Objectives At the conclusion of this session, the participant will be able to: • understand potential mechanisms by which elevated CO2 may increase morality and morbidity • identify reduction in PCO2 as an important treatment strategy for patients with chronic hypercapnic respiratory failure • more effectively utilize both the sleep lab and home monitoring strategies to manage patients on NIV Chronic hypercapnia has long been seen as simply a marker of severity of disease as opposed to a condition that is treatable. Recent studies have shown the high mortality and health care utilization associated with chronic hypercapnia. Non-invasive ventilation (NIV) has been shown to improve survival in patients with COPD, OHS, and ALS. This session will provide the biological mechanisms by which chronically elevated PCO2 may increase morbidity and mortality, review clinical research (Jimenez et al, Respiratory Care, 2023) demonstrating the importance of reductions in PCO2 over time, and compare in-lab versus at home monitoring strategies to optimize home mechanical ventilation. 11:00 Introduction to Session 11:05 Under Attack: Co2 Effects on Host Immune Defenses 11:22 Skeletal Muscle Dysfunction: An Added Insult in Chronic Hypercapnic Respiratory Failure 11:39 Hypercapnic No More: Mobilizing CO2 Stores with NIV to Improve Survival Marriott Marquis San Diego Marina Grand Ballroom 2-4 (Lobby Level, North Tower)

BASIC • CLINICAL • TRANSLATIONAL MINI SYMPOSIUM

D91 BRIDGING THE GAP: TRANSLATIONAL STUDIES IN ARDS, PNEUMONIA, AND SEPSIS 11:00 a.m. - 1:00 p.m. Marriott Marquis San Diego Marina Pacific Ballroom 18-19 (Ground Floor, North Tower) Oral Presentations: 11:00 42-gene Severe-or-Mild (SoM) Gene Expression Signature Is Conserved Across Viral and Bacterial Infections and Is Associated With Differential Response to Steroids in Septic Shock 11:12 A Lung-specific Metabolic Signature From Heat and Moisture Exchange (HME) Filter Metabolomic Analysis Is Distinct From Plasma Signal in Acute Respiratory Distress Syndrome 11:24 A Prospective Machine Learning Model for the Identification of Acute Respiratory Distress Syndrome (ARDS) Sub-phenotypes 11:36 Single Nucleotide Variation in CX3CL1 and Risk for Bacterial Pneumonia and ARDS 11:48 Surfactant Protein B Reduces Respiratory Viral Infectivity in Human Lungs 12:00 Association of CC16 Expression in the Airways With Signature Expression of Multi-omics Data 12:12 Transcriptome-based Prediction of COVID-19 Symptom Development: Insights From Nasal Epithelium Analysis 12:24 Patient-reported Symptoms Do Not Correlate With Immune Profiling in Multi-omics Analysis of Post-acute Sequelae of COVID-19 12:36 Human Red Blood Cells Express Toll-like Receptor 7 and Bind Single Stranded RNA 12:48 Type I Interferon Autoantibodies Are Not Associated With the Development of Long COVID

ATS 2024 • San Diego, CA