ATS 2024 Final Program

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340

WEDNESDAY • MAY 22

BASIC • TRANSLATIONAL MINI SYMPOSIUM

BASIC • TRANSLATIONAL MINI SYMPOSIUM

D96 BREATH BEYOND: NOVEL INSIGHTS IN LUNG INJURY 11:00 a.m. - 1:00 p.m. Marriott Marquis San Diego Marina Grand Ballroom 8-9 (Lobby Level, North Tower) Featured Speaker Presentation: 11:00 Mitochondrial DNA in Pulmonary Innate Immune Responses Oral Presentations: 11:12 Caspase-1-licensed Lung Epithelial Cell Pyroptosis Drives Neutrophil Necroptosis to Dampen Immune Defense Against Bacterial Infection 11:24 Influenza A Virus Subverts the Proteasome to Inhibit Degradation of Polyubiquitinated BIK, Promoting Viral Replication in the Airway Epithelial Cells 11:36 Interferon Responses in Down’S Syndrome Airway Epithelial Cells Are Altered During RSV Infection 11:48 TREK-1 Potassium Channels Protect Against Influenza-A-induced ARDS 12:00 Macrophage-Epithelial Communication Determines Lung Mechano-Immune Responses to Hyperinflation 12:12 Receptor for Advanced Glycation Endproducts-Dependent Endogenous IL-33 Release and Group 2 Innate Lymphoid Cells Accumulation Contribute to Lung Ischemia-reperfusion Injury 12:24 Loss of the Thrombin Receptor PAR1 in Lymphatic Endothelial Cells Exacerbates Acute Lung Injury in a Mouse Model of ARDS 12:36 Bone Morphogenetic Protein 10 Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Alleviating Pulmonary Endothelial Dysfunction and Injury 12:48 Activating the Apical Epithelial Sodium Channel Alpha Subunit With the TIP Peptide Preserves Alveolar Fluid Clearance and Reduces Pulmonary Edema in the Ex Vivo Perfused Human Lung Injured by S. Pneumoniae

D97 FEELING STUCK? MECHANISMS OF MUCOCILIARY (DYS)FUNCTION 11:00 a.m. - 1:00 p.m. Marriott Marquis San Diego Marina Grand Ballroom 11-13 (Lobby Level, North Tower) Oral Presentations: 11:00 Loss of Sialylation Compacts Mucin and Impairs Mucociliary Transport 11:12 Loss of AC6 Drives Mucociliary Clearance Defects 11:24 Unrecognized Ciliary Motility Disorders in Neutrophilic Severe Asthma Exacerbations 11:36 Disruption of the DNAI1 Gene in Pigs Produces a Model of Primary Ciliary Dyskinesia 11:48 Nasal and Lower Airway Cilia Function in Bronchiectasis 12:00 Muc5b and Muc5ac Are Required for Virus-induced Airway Hyperresponsiveness and Antiviral Immunity 12:12 Pulmonary Long COVID Patients Have Abnormal Airway Mucosa: Insights From Single-cell RNA Sequencing 12:24 Trikafta Use in NCFB Patients With a Single Disease Causing CFTR Mutation and Evidence of CFTR Dysfunction 12:36 Bioengineering an Ex Vivo Whole Porcine Lung Model of Cystic Fibrosis to Enable Therapeutic Screening BASIC • BEHAVIORAL • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION D101 UNCOVERING THE METABOLIC AND GENETIC UNSOLVED MYSTERIES IN ASTHMA 11:00 a.m. - 1:00 p.m. San Diego Convention Center Room 33A-C (Upper Level) Poster Viewing 11:00-11:45 Discussion 11:45-1:00

ATS 2024 • San Diego, CA