ATS 2024 Final Program

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347

WEDNESDAY • MAY 22

121 Case Report of Plastic Bronchitis Characterized by Refractory Hemoptysis 122 Simultaneous Co-infections of Opportunistic Pathogens in Newly Diagnosed HIV Patient: A Hickam’s Dictum 123 Uncontrollable Production of a Large Volume of Sputum With Marked Reduction Following SARS-CoV-2 Infection 124 Separating Out Pulmonary Sequestration

609 Bronchial Field Basal Cells Show Long-term Methylome-wide Impact of Smoking Persists Indefinitely After Smoking Cessation 610 Prospective Genetic Sequencing Amongst Non-Cystic Fibrosis Bronchiectasis Patients 611 Single Cell RNA Sequencing Reveals the Link Between Cannabis Smoking and Immune Dysregulation in the Airway Epithelium 612 Shuttle Peptide Achieves Intracellular Airway Delivery of Phosphorodiamidate Morpholino Oligonucleotide (PMO) in Mucus Hypersecretion Lung Environment 613 Neutrophil Elastase Regulates CFTR Function in Chronic Neutrophilic Lung Disease 614 The Mechanogenetic Role of microRNA in Asthmatic Bronchoconstriction 615 Interleukin 36? (IL-36 g ) Drives Airway Epithelial Remodeling and Is Associated With Non-T2 Airway Inflammation in Obese Asthma 616 Signaling Pathway Underlying TNF a -induced Proliferation of Human Airway Smooth Muscle Cells 617 Identification of a Novel Fibroblast Subpopulation Using Single-cell RNA Sequencing Following Airway Reconstruction 618 Novel Anti-inflammatory and Immunomodulatory Effects of the Dipeptidyl Peptidase-1 Inhibitor Brensocatib: A Post-hoc Analysis of the WILLOW Trial 619 A Novel SHC Inhibitor (SHC#301) Mitigates Alloimmune-mediated Airway Fibrosis 620 Sputum Dipeptidyl Peptidase-1 Activity Associates With Inflammation and Disease Severity in Bronchiectasis: Data From the EMBARC-BRIDGE Study 621 CFTR Modulators Reprogram Sex-Specific Airway Neutrophil Signaling 622 A Novel Ligand-Selective Anti-Notch2 Antibody Induces Secretory to Ciliated Cell Transdifferentiation in Rodent Airways, and Is a Promising Candidate for Treating Muco-obstructive Airway Disease 623 Early Human Lung Immune Cell Development and Its Role in Epithelial Cell Fate

CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION

D108 SIGNALING PATHWAYS IN AIRWAY REGENERATION AND REPAIR 11:00 a.m. - 1:00 p.m. San Diego Convention Center Room 5A-B (Upper Level) Poster Viewing 11:00-11:45 Discussion 11:45-1:00 601 RB Transcriptional Corepressor-like 2 Depletion Increases Self-renewal and Sustains Differentiation Capacity in Primary Human Airway Epithelial Cells 602 Claudin-18 Regulates Airway Progenitor Cell Homeostasis and Differentiation 603 FOXM1 Inhibits Airway Epithelial Tight Junction Molecule Claudin9 Expression and Is Involved in Epithelial Barrier Disruption 604 Early Activation of Distal Lung Airway Progenitors Signifies a Role of Intermediate Filaments in Alveolar Regeneration 605 MTOR Signaling Regulates Aberrant Epithelial Cell Proliferative and Migratory Behaviors Characteristic of Airway Mucous Metaplasia in Asthma 606 Cellular Responses to Motile Cilia Dysfunction in the Mouse Airway Ciliary Microenvironment 607 MIA3 Is a Specialized Trafficking Protein That Is Required for MUC5AC Production 608 Autophagy Regulates Lysosome-mediated Degradation of Mucin Granules

ATS 2024 • San Diego, CA