ATS Pulmonary Function Laboratory Manual

ATS Pulmonary Function Laboratory Management & Procedure Manual | 3rd Edition

4. Inhalation of mannitol may cause coughing and/or dry throat. You can offer the patient water to sip during and after the challenge test. 5. The mannitol challenge test is time critical and requires an osmotic gradient to be established and maintained. Prolonged intervals between doses may affect the validity of the test results and should be avoided. References 1. Anderson SD, Brannan J, Spring J, Spalding N, Rodwell LT, Chan K, Gonda I, Walsh A, Clark AR. A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 1997;156:758–765. 2. Brannan JD, Koskela H, Anderson SD, Chew N. Inhaled mannitol identifies responsiveness to eucapnic hyperventilation. Am J Respir Crit Care Med 1998;158:1120–1126. 3. Anderson SD. Indirect challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 2010; 138(2, Suppl)25S–30S. 4. Brannan JD, Koskela H, Anderson SD, Chan HK. Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology 2002;7:37–44. 5. Leuppi JD, Brannan JD, Anderson SD. Bronchial provocation tests: the rationale for using inhaled man- nitol as a test for airway hyperresponsiveness. Swiss Med Wkly 2002;132:151–158. 6. Leuppi JD, Salome CM, Jenkins CR, Anderson SD, Xuan W, Marks GB, Koskela H, Brannan JD, Freed R, Andersson M, et al . Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. Am J Respir Crit Care Med 2001;163:406–412. 7. ARIDOL®PrescribingInformation[accessed2014Mar].Available from:http://www.us.aridol.info/home. 8. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, et al .; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J 2005;26:319–338. 9. Subbarao P, Brannan JD, Ho BJ, Anderson SD, Chan H-K, Coates AL. Inhaled mannitol identifies methacholine-responsive children with active asthma. Pediatr Pulmonol 2000;29:291–298.

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