Final-Program-ATS-2023-AP.vp

108

SUNDAY • MAY 21

2:15

The Case of the Labored BreathS. Gorvetzian, MD, Aurora, CO When You Hear Hoofbeats L. Power, MBBCh, MRCPI, Galway, Ireland

BASIC • TRANSLATIONAL BASIC SCIENCE CORE CME Credits Available: 1.5

2:27

2:39

A Zebra Walks into the ICU M. Richert, MD, Bethesda, MD

A85

PHYSIOLOGICAL AND CELLULAR IMPACT OF ENVIRONMENTAL EXPOSURES

2:51

What if It’s Not Just Air in There? P. Sekhon, MBBS, MD, Brooklyn, NY Master Clinician A.E. O’Donnell, MD, Washington, DC Master Clinician M. Kreider, MD, Philadelphia, NY

2:15-3:45pm

Location: Marriott Marquis Washington Independence Ballroom, Salons E-H

3:03

Target Audience Researchers and clinicians Objectives

3:10

3:17

Master Clinician P.C. Stillwell, MD, Aurora, CO

At the conclusion of this session, the participant will be able to: • identify opportunities for novel investigation into understudied aspects of the impact of environmental exposure of cellular and biological pathways relevant to lung disease. • learn how advances in epidemiological studies are revealing new knowledge on health effects of environmental exposures. • learn how advances in lung biology are revealing how environmental exposures can alter the pulmonary immune response and disease susceptibility. This is part 2 of a 2-part symposium. Part 1 is on Sunday, May 21, 9:00 a.m. -10:30 a.m. focuses on quantification of environmental exposures using state-of-the-art methods. Part 2 focuses on the physiological and cellular impact of environmental exposures. Occupational and environmental lung diseases are caused by the inhalation of chemical irritants, allergens or toxins in work or home environments. Most diseases are caused by repeated, long-term exposure, but even a one-time or indirect contact with a hazardous agent can result in lung diseases with lasting effects. Environmental exposures related to fossil fuel and heavy metals and occupational exposures related to silica and coal mining generate oxidative stress and inflammation in the lungs. Sustained oxidative stress causes DNA damage, epigenetic instability, mitochondrial dysfunction, and cell cycle arrest in key progenitor cells in the lung. Inhaled environmental exposures accelerate lung aging by injuring the lungs and damaging the cells responsible for wound healing. Novel exposure assessment methods, including functional imaging and -omics studies, together with mathematical models are needed to quantify environmental exposures. Interventions that minimize exposure to noxious antigens are critical to improve lung health, and novel research is required to expand our knowledge of therapies that may slow or prevent premature lung aging. Each presentation will leave 5 minutes for questions and answers.

3:24

Master Clinician J.B. Taylor, MD, MSCR, Pittsburgh, PA

3:31 Pathology Findings

J.L. Myers, MD, Ann Arbor, MI

3:38

Radiological Findings

P. Bergquist, Washington, DCBASIC • CLINICAL CLINICAL TOPICS IN PULMONARY MEDICINE CME Credits Available: 1.5 NEW ENGLAND JOURNAL OF MEDICINE AND JAMA. DISCUSSION ON THE EDGE: REPORTS OF RECENTLY PUBLISHED PULMONARY RESEARCH This session will provide a forum for attendees to interact with the authors and editors about papers published in the New England Journal of Medicine and JAMA. Papers presented will be recent publications, selected by the editors, to be of significant importance to the field of pulmonary medicine. Attendees will have the opportunity to hear presentations directly from the author and address questions to both the authors and editors. The discussion is intended to provide a unique insight into these papers, the selection process, and how the research applies directly to the field of pulmonary medicine. Chairing: D. Taichman, MD, Boston, MA G. O'Connor, MD, Boston, MA Speakers and Talks To Be Announced A84 2:15-3:45 PM Walter E. Washington Convention Center Room 207 A-B (Level 2)

ATS 2023 • Washington, DC