Final-Program-ATS-2023-AP.vp

SUNDAY • MAY 21

121

419 Identification and Analysis of Secretome of IPF Senescent Human Lung Fibroblasts Using ER-BioID2 Revealed Profibrotic Proteins Profile Involved Extracellular Matrix Remodeling/ N.D. Vanegas, Columbus, OH 420 The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging/ Y. Yuan, New Haven, CT 421 Cellular Senescence Is Associated With Extracellular Matrix Dysregulation in COPD/ C.-A. Brandsma, Groningen, Netherlands 422 Senescent Cells Suppress Macrophage-mediated Corpse Removal Via Upregulation of the CD47-QPCT/l Axis/ D. Schloesser, Biberach an der Riss, Germany 423 AMPK Stimulates Recovery From Aging-impaired Efferocytosis and Promotes Lung Fibrosis Resolution in Aged Mice/ J.W. Zmijewski, Birmingham, AL 424 Lung-Targeted Delivery of Nrf2 Activators Promotes the Reversal of Age-Dependent Established Lung Fibrosis/ K. Kato, Atlanta, GA 425 Bleomycin Induces Chronic Progressive Pulmonary Fibrosis in Premature Aging Ercc1 D / - Mice/ T. Koudstaal, Rotterdam, Netherlands

403 Cellular Ageing and Senescence Transcriptional Modules in the Aged Human Lung/ R. De Man, New Haven, CT 404 Mitochondrial Response to Telomere Dysfunction-induced Cellular Senescence/ D.I. Sullivan, Pittsburgh, PA 405 Regulation of Senescence and Mitochondrial Function by CD148 in Idiopathic Pulmonary Fibrosis Alveolar Epithelial Cells/ B.J. Moss, Houston, TX 406 Loss of ANT1 Increases Fibrosis and Senescence in Idiopathic Pulmonary Fibrosis/ J. Sui, Pittsburgh, PA 407 Chronic WNT/ß-catenin Signaling Impairs Mitochondrial Function in Lung Epithelial Cells/ Q. Hu, Pittsburgh, PA 408 Age-dependent Loss of Alveolar Type II Cells and Impaired Proliferation in a Murine Model of Hermansky-Pudlak Syndrome-related Pulmonary Fibrosis/ J. Wang, Philadelphia, PA 409 Lipid Deficiency Contributes to Impaired Alveolar Progenitor Cell Function in Aging and Idiopathic Pulmonary Fibrosis/ C.J. Liang, Los Angeles, CA 410 HDAC9 Deficiency Drives Impaired Lipid Metabolism During Chronic Inflammation in the Aged Lung/ E. Avci, Bad Nauheim, Germany 411 Non-canonical Pathways Involving the Glycolytic Enzyme PGK1 Mediate Myofibroblast Differentiation in Age-related Lung Fibrosis/ G. Roda, Aurora, CO 412 Transitional Alveolar Type 2 Cells Acquire Senescent Features in Association With Proteostasis Defects/ B. Deskin, New Orleans, LA 413 XBP1 Is a Key Regulator of the Cellular Stress Response and Senescence in AT2 Progenitor Cells Promoting Resilience to Lung Injury/ J. Calyeca, Columbus, OH 414 Senescence or Autophagy, Divergent Mechanisms Driving Alveolar Regeneration in Accelerated Aging Mice/ Y. Romero, Mexico City, Mexico 415 Syndecan-1 Regulates Alveolar Type 2 Epithelial Cell Senescence Through Autophagy During Lung Fibrosis/ Z. Ortega, Los Angeles, CA 416 Hermansky Pudlak Syndrome-1 (HPS-1) Lung Fibroblasts Show a Profibrotic Phenotype Characterized by Decreased Slc7a11, a Phenotype Shared by Aging and IPF Lungs/ J. Roman, Philadelphia, PA 417 IL-17A Augments Cellular Senescence in Fibrotic Pulmonary Disease/ S.B. Shaikh, Rochester, NY 418 Senolysis by Targeting Metabolic Reprogramming in Senescent Lung Fibroblasts/ G. Liu, Birmingham, AL

BASIC • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION

A108 NEW INSIGHTS INTO CHRONIC

OBSTRUCTIVE PULMONARY DISEASE

2:15 p.m. - 4:15 p.m.

Marriott Marquis Washington Marquis Ballroom, Salons 3-4 (Level M2)

Poster Viewing

2:15-3:00 3:00-4:15

Discussion

Chairing: F. Polverino, MD, PhD, Houston, TX

R. Zakarya, BSc(Hons), PhD, Sydney, Australia 901 CRISPR Interference (CRISPRi) of Chronic Obstructive Pulmonary Disease (COPD) GWAS Genes in IPSC Derived Alveolar Type 2 (iPSC-AT2) Cells Reveals Similar Transcriptomic Aberrations in DSP and ADGRG6 Knockdown/ V. Malik, Boston, MA 902 The Gycopolymer PAAG Improves MCT in Trachea

Derived From a Ferret Model of COPD and Bronchitis/ S.S. Hussain, Birmingham, AL

ATS 2023 • Washington, DC