Final-Program-ATS-2023-AP.vp

130

MONDAY • MAY 22

Chairing: N. Ayas, MPH, MD, Vancouver, Canada

• define the current state-of-the-art management of the acute and chronic pulmonary complications of sickle cell disease and identify knowledge gaps that exist • understand the impact of abnormalities throughout the pulmonary system (airway, gas exchange/sleep, and vascular) as disease modifiers on SCD outcomes throughout the lifespan • gain an understanding of the mechanisms of new SCD disease-modifying therapies including hematopoietic stem cell transplantation and gene therapy on overall disease progression and potential impacts on cardiopulmonary dysfunction SCD affects approximately 100,000 US individuals, and 300,000 births annually worldwide, largely on the African continent. While it is a genetic hemoglobinopathy, SCD is a systemic disorder. In the lungs, nearly every cell type and structure are affected, and cardiopulmonary complications are a leading cause of morbidity and accelerated mortality. The goal of this scientific symposium is to present recent findings and evidence-based interventions for acute and chronic pulmonary complications of SCD across the lifespan. We will actively engage pediatric and adult clinicians and researchers to promote collaborative investigation and implementation of evidence-based clinical care for patients living with SCD. Chairing: R.T. Cohen, MD, MPH, Boston, MA A.P. Ruhl, MD, MHS, Bethesda, MD E.S. Klings, MD, Boston, MA S.C. Sadreameli, MD, MHS, Baltimore, MD 9:00 Introduction R.T. Cohen, MD, MPH, Boston, MA 9:03 Patient Speaker T. Woolford, Owings Mills, MD 9:08 A Pulmonary Perspective of Sickle Cell Disease and Disease-Modifying Therapies A. Campbell, MD, Washington, DC 9:21 Airway Function in SCD: Impact on Morbidity and Mortality Across the Lifespan S.M. Willen, MD, Sacramento, CA 9:34 Sleep Disordered Breathing in SCD - What Have We Learned? O. Afolabi-Brown, MD, Philadelphia, PA 9:47 Pulmonary Hypertension Beyond the ATS Guidelines: New Concepts in Pathophysiology, Diagnosis and Treatment R.F. Machado, MD, Indianapolis, IN 10:00 Acute Chest Syndrome and Venous Thromboembolism in SCD: When the Acute Becomes Chronic E.S. Klings, MD, Boston, MA 10:13 Curative Therapies for Sickle Cell Disease: Potential Cures for SCD but What About the Lung? C. Fitzhugh, MD, Bethesda, MD 10:26 Conclusion A.P. Ruhl, MD, MHS, Bethesda, MD

F.R. Almeida, PhD, DDSc, Vancouver, Canada V.Y. Polotsky, MD, PhD, Baltimore, MD A. Parekh, PhD, New York, NY S.S. Redline, MD, MPH, Boston, MA

9:00 Introduction

N. Ayas, MPH, MD, Vancouver, Canada

9:02 Patient Perspective

Speaker To Be Announced 9:07 What’s New with Weight Loss, Oral Appliances, and Upper Airway Surgery? B.A. Edwards, PhD, Melbourne, Australia 9:21 Electrical Stimulation: Hypoglossal Nerve Stimulation, Ansa Cervicale Stimulation, and Transoral Daytime Neurostimulation D. Kent, MD, Nashville, TN 9:35 Clinical Drug Discovery Based on Endotypes C.N. Schmickl, MD, PhD, San Diego, CA 9:49 Preclinical Drug Discovery: Cannabimimetics, Intranasal Leptin, DREADD, and Beyond B. Prasad, MD, ATSF, Chicago, IL 10:03 FDA Perspective: Regulatory Considerations for the Development of New OSA Therapies 1 L. Kim, MD, Silver Spring, MD 10:10 FDA Perspective: Regulatory Considerations for the Development of New OSA Therapies 2 N.A. Weir, MD, Silver Spring, MD 10:17 Panel Discussion Plus Q&A S.S. Redline, MD, MPH, Boston, MA

CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

CME Credits Available: 1.5 MOC Points Available: 1.5

B7

SICKLE CELL LUNG DISEASE ACROSS THE LIFESPAN: WHERE ARE WE NOW?

Assemblies on Pediatrics; Behavioral Science and Health Services Research; Clinical Problems; Critical Care; Nursing; Pulmonary Circulation; Sleep and Respiratory Neurobiology 9:00 a.m. - 10:30 a.m. Target Audience Pediatric and adult pulmonary, critical care, and sleep trainees, and clinicians and researchers interested in the pulmonary complications of sickle cell disease (SCD) across the lifespan Objectives At the conclusion of this session, the participant will be able to:

ATS 2023 • Washington, DC