Final-Program-ATS-2023-AP.vp

MONDAY • MAY 22

131

9:26 Retinal Involvement in PAH T. Lahm, MD, ATSF, Denver, CO 9:38 Questions/Discussion 9:42 Gut Microbiome and Systemic Inflammation in PAH T. Thenappan, MD, Minneapolis, MN 9:54 Questions/Discussion 9:58 Obesity and Metabolic Dysfunction in PAH N. Al-Naamani, MD, MS, Philadelphia, PA 10:10 Questions/Discussion 10:14 Skeletal Muscle and Exercise in PAH E. Brittain, MD, Nashville, TN 10:26 Questions/Discussion This session and the International Conference are supported by an independent medical educational grant from Merck & Co. All CME sessions have been planned and implemented in accordance with the Accreditation Criteria of the Accreditation Council for Continuing Medical Education (ACCME®) and are free of the control of ineligible companies (formerly commercial interests). B9 SEX-SPECIFIC MECHANISMS OF LUNG DISEASE PATHOGENESIS THROUGH THE LENS OF SINGLE CELL RNA SEQUENCING Assemblies on Respiratory Cell and Molecular Biology; Allergy, Immunology and Inflammation; Respiratory Structure and Function 9:00 AM - 10:30 AM Marriott Marquis Washington Marquis Ballroom Salon 5 (Level M2) Target Audience Health professionals and life scientists interested in lung disease pathogenesis, and trainees in biomedical research interested in single cell profiling studies, bioinformatics, and the role of sex on lung disease pathogenesis Objectives At the conclusion of this session, the participant will be able to: • describe recent findings from scRNAseq analyses that improved our understanding of sex-based lung disease pathogenesis • understand the role and limitations of single cell profiling in the future of clinical pulmonary medicine with an emphasis on sexually dimorphic clinical features • define emerging single-cell technologies and analytic techniques for the study of lung disease and outline a pathway to properly sample, process, and analyze samples for sex-specific studies BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 1.5

BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

CME Credits Available: 1.5 MOC Points Available: 1.5

B8

BEYOND THE LUNGS: EXTRAPULMONARY MANIFESTATIONS OF PULMONARY VASCULAR DISEASE

Assembly on Pulmonary Circulation 9:00 a.m. - 10:30 a.m.

Marriott Marquis Washington Liberty Ballroom Salons I-L (Level M4)

Target Audience Providers caring for those with pulmonary vascular disease, and those with clinical or research responsibilities related to pulmonary vascular disease or lung diseases with similar extrapulmonary manifestations Objectives At the conclusion of this session, the participant will be able to: • describe new findings about extrapulmonary manifestations in PAH within the CNS, skeletal musculature, gut microbiome and changes in systemic inflammation, endocrine and metabolic function • define new strategies to manage the care of PAH including the role that pulmonary rehabilitation may play and how novel therapeutic targets addressing inflammation and metabolism may prove to improve clinical outcomes • apply new findings toward novel research questions and continue investigation of how these systemic effects of PAH may play a role in disease development and outcomes This session will provide a comprehensive review of extrapulmonary manifestations of pulmonary arterial hypertension (PAH). Several systems will be reviewed including the central nervous system, skeletal musculature, endocrinological manifestations and the immune system. Presenters will provide a review of the literature from bench to bedside observations and proposed pathophysiological mechanisms. Therapeutic implications and knowledge gaps will also be highlighted. By the conclusion of this session, learners will understand how PAH may affect multiple extrapulmonary systems and how the multi-system interplay in the development of this

complex disease may contribute to clinical outcomes. Chairing: S. Umar, MD, PhD, Los Angeles, CA

A. Hemnes, MD, ATSF, Nashville, TN N. Singh, MD, MBA, Providence, RI

9:00 Welcome and Introductions 9:05 Patient Speaker Speaker To Be Announced 9:10 Spinal Cord Neuroinflammation in PAH S. Umar, MD, PhD, Los Angeles, CA 9:22 Questions/Discussion

ATS 2023 • Washington, DC