Final-Program-ATS-2023-AP.vp

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MONDAY • MAY 22

1021 Comparison of the Old (2005) and New (2021) ATS/ERS Methods for Assessing Bronchodilator Response (BDR) by FEV1 in a Clinical Trial for Asthma/ K. Mccarthy, Matthews, NC 1022 Feasibility of Achieving the 2019 ATS-ERS Spirometry FIVC Acceptability Standard Among Patients With Nonspecific Pattern of Lung Dysfunction/ R. Eggleston, Rochester, MN 1023 Application of GLI Global Spirometry Reference Equations to a Large Population Across a Multi-site Academic Healthcare System/ A. Kanj, Rochester, MN 1024 Proportional Tidal Volume Variation During

P686 Circadian Clock Rev-erb a Role in the Recruitment of Immune Cells Into the Lung During Chronic House Dust Mite-induced Allergic Asthma/ S.K. Duraisamy, Kansas City, KS P687 Pulmonary Hypertension Is Associated With Higher Mortality and Worse Outcomes in Asthma Exacerbation Related Hospitalizations/ A. Aboelnasr, Cincinnati, OH P688 Atrial Fibrillation, Supraventricular Tachyarrhythmias and Ventricular Arrhythmias Are Associated With Higher Mortality and Worse Outcomes in Asthma Exacerbation Hospitalizations/ A.A. Aboelnasr, Cincinnati, OH P689 Increased Platelet Counts Are Associated With Female Sex and Asthma Severity/ N. Solanki, Cleveland, OH P690 Associations Between Asthma Control, Adherence and Short-Acting Beta 2 -Agonist (SABA) Use in Patients With Uncontrolled Asthma Using a Maintenance and Reliever Digital System (MRDS)/ G. Mosnaim, Evanston, IL P691 The Effect of Chronic Allergic Lung Inflammation on Gut Microbiota and Depression in Mice/ A. Kanaya, New York, NY P692 Gasdermin B Is an RNA Sensor That Promotes Interferon Response and Airway Inflammation/ T. Liu, Boston, MA P693 BNT162b2 mRNA Covid-19 Vaccine Increases the Sensitivity to Histamine in a Human Ex Vivo Model of Severe Eosinophilic Asthma/ L. Calzetta, Parma, Italy P694 BNT162b2 mRNA Covid-19 Vaccine Increases the Contractility to Parasympathetic Activation in a Human Ex Vivo Model of Severe Eosinophilic Asthma/ L. Calzetta, Parma, Italy P695 Particulate Matter Induces Lung Inflammation in Healthy Mice and Exacerbates Experimental Asthma Model Animals/ I.C. Tiberio, Sao Paulo, Brazil P696 Rhinovirus Infection Induces Endothelin-1 Secretion From Human Bronchial Epithelial Cells and in Mouse Models of Allergic Airway Disease/ A.B.C. Dy, Boston, MA P697 Phenotyping Nasal Epithelial Cells in Severe Eosinophilic Asthma Patients/ K.L. Raby, London, United Kingdom P698 Modulating the Level of ICS in Triple ICS/LABA/LAMA FDC: Effect Against Inflammation in a Human Ex Vivo Model of Severe Eosinophilic Asthma/ P. Rogliani, Roma, Italy P699 Periostin Induction by MicroRNAs Associated With Neutrophilic Airway Inflammation in Asthma/ V. Dubovik, New Haven, CT P700 The Role of Myeloid-derived Suppressor Cells in a Murine Model of Influenza Virus-induced Asthma Exacerbation/ S. Kolahian, Marburg, Germany P701 Long-term Metformin Use Is Not Associated With Lower Risk of Asthma Exacerbations/ P. Zhang, Cleveland, OH

Cardio-pulmonary Exercise Testing to Diagnose Dysfunctional Breathing in Patients With Exertional Dyspnoea/ M.H. Brutsche, St. Gallen, Switzerland

BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION

B31

ASTHMA: FROM MICE TO MEN, AND BACK AGAIN

9:00 a.m. - 4:15 p.m.

Walter E. Washington Convention Center Area G, Hall C (Lower Level)

Viewing: Posters will be on display for entire session

11:30-1:15

Discussion: 11:30-12:15 authors will be present for individual discussion 12:15-1:15 authors will be present for discussionwith assigned facilitators. P679 Precision Medicine for Asthma and Eosinophilic Inflammation in Exacerbations/ E. Scott, Baltimore, MD P680 Role of Type 2 Immunity in the Context of IFN- g High/Type 1High Severe Asthma/ S.L. Kale, Pittsburgh, PA P681 Glucagon Like Peptide-1 Receptor Signaling Suppresses Pulmonary Macrophage Migration Inhibitory Factor and CD74 Expression/ J.T. Womble, Durham, NC P682 A Phase 1 First-in-Human Single Ascending-dose Study With a Novel Antibody to the Human Thymic Stromal Lymphopoietin Receptor/ A. Deykin, Waltham, MA P683 Novel Machine Learning Identifies Five Asthma Phenotypes Using Cluster Analysis of Real-world Data/ C. Wu, Cleveland, OH P684 Chronic Allergic Lung Inflammation Induced by Intranasal House Dust Mite Antigen Causes Suppression of Neuronal Activity in Mice/ M. Trichas, New York, NY

P685 Functional Analysis of Sputum Eosinophil

Subpopulations in Children With Asthma/ G. Wilson, New Haven, CT

ATS 2023 • Washington, DC