Final-Program-ATS-2023-AP.vp

MONDAY • MAY 22

197

on maintaining community participation. Optimizing evidence based respiratory assistive device adaptations to continue appropriate ventilation and airway clearance while out of the home. Specific situations that will be addressed will be sports participation (skiing, hockey), camping and day and multi-day travel. Patient and family panelists will provide expert experiential guidance. Chairing: K.A. Provost, DO, PhD, FCCP, Buffalo, NY M. Cao, DO, STANFORD, CA J.H. Hansen-Flaschen, MD, ATSF, Wynnewood, PA 2:15 Why Am I Carrying All of This STUFF? K.A. Provost, DO, PhD, FCCP, Buffalo, NY 2:30 You Are Going to School Today! R. Amin, MD, Toronto, Canada 2:45 Ventilators in the Wild! Skiing, Camping and Other Sports J.P. Brown, MD, PhD, Salt Lake City, UT 3:00 London/Disneyworld/Laguna Beach Here We Come! L.F. Wolfe, MD, Chicago, IL 3:15 No Really, You Really Can Do All This! M. Lindquist, L. Lindquist, Buffalo, NY 3:25 Speaker Panel B84 NEXT GENERATION CRITICAL CARE TRIALS: FROM PRAGMATIC TRIALS TO PRECISION MEDICINE Assemblies on Critical Care; Behavioral Science and Health Services Research; Nursing 2:15 PM - 3:45 PM Walter E. Washington Convention Center West Salon G-I (Street Level) Target Audience Clinicians of any discipline who care for critically ill adults or children, and clinical and translational critical care researchers Objectives At the conclusion of this session, the participant will be able to: • researchers who attend the session will be able to apply knowledge acquired about novel trial designs to interpret and critique the results of future platform, adaptive, pragmatic, and personalized clinical trials • clinicians will be able to assess the strengths and limitations of novel trial designs in order to facilitate the implementation of results from future trials into clinical practice to improve patient outcomes CLINICAL CRITICAL CARE TRACK CME Credits Available: 1.5

• learners will be able to apply an understanding of “individual treatment effect” and “personalized medicine” to the manner in which they implement the results of clinical trials into clinical practice Critical care has historically relied on explanatory, parallel-group randomized trials to generate evidence to inform practice. Such designs can be inefficient and expensive. COVID-19 has changed the landscape of critical care trials by advancing alternative, innovative, and efficient approaches to trial design, conduct, and analysis. This session will review these new methods, including platform trials, adaptive trials, Bayesian methods, pragmatic trials, and trials informing personalized treatment choices. Clinicians will learn how to interpret and apply results of these trials to practice. Researchers will learn how to use these methods to generate real-world, personalized evidence, improving care for critically ill patients. Chairing: M.W. Semler, MD, MSc, Nashville, TN C.S. Calfee, MD, MSCR, San Francisco, CA M.M. Churpek, MD, MPH, PhD, ATSF, Madison, WI 2:15 Introduction: ABCs of Next-Gen RCTs M.W. Semler, MD, MSc, Nashville, TN 2:20 Platform Trials M.N. Gong, MS, MD, Bronx, NY 2:35 Adaptive Trials and Bayesian Methods E. Goligher, MD, PhD, Toronto, Canada 2:50 Pragmatic Trials J.D. Casey, MD, MSCR, Nashville, TN 3:05 Using Biomarkers for Precision Medicine in Clinical Trials C.S. Calfee, MD, MSCR, San Francisco, CA 3:20 Using Machine Learning for Precision Medicine in Clinical Trials M.M. Churpek, MD, MPH, PhD, ATSF, Madison, WI 3:35 Roundtable Discussion M.W. Semler, MD, MSc, Nashville, TN

BASIC • TRANSLATIONAL BASIC SCIENCE CORE CME Credits Available: 1.5

B85

PROCESSING THE ENVIRONMENT: LUNG LYMPHATICS AND FOLLICLES IN DISEASE

Assemblies on Respiratory Structure and Function; Allergy, Immunology and Inflammation; Respiratory Cell and Molecular Biology 2:15 PM - 3:45 PM Marriott Marquis Washington Independence Ballroom Salons E-H (Level M4) Target Audience Lung health providers, trainees, and those involved in research or clinical care related to lung disease and immune response

ATS 2023 • Washington, DC