Final-Program-ATS-2023-AP.vp

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MONDAY • MAY 22

see patients hospitalized with pneumonia, and all basic, translational or clinical researchers with an interest in pneumonia, critical care, phenotypes and endotypes Objectives At the conclusion of this session, the participant will be able to: • improve precision in the diagnosis and management of patients with pneumonia utilizing clinically available resources like guidelines and culture-independent diagnostic tools • understand the existing phenotypes and endotypes in pneumonia and methods to evaluate their trajectory over time • define and implement research strategies to characterize patients with pneumonia Pneumonia is a leading cause of death globally. With the current approach to pneumonia, which includes diagnosis by symptoms and chest radiograph and management with antibiotics, morbidity and mortality remain high. Precision medicine calls for multidimensional characterization of a patient to identify factors that may indicate favorable responses to an intervention. The identification of phenotypes and endotypes are crucial for the development of targeted therapies in pneumonia. In this session, experts will introduce the audience to emerging research that supports the presence of phenotypes in pneumonia and discuss clinical tools that can enhance precision medicine in pneumonia. Chairing: C. Pickens, MD, Chicago, IL B.G. Wu, MD, MSc, New York, NY R.P. Dickson, MD, Ann Arbor, MI 2:15 Matching Solutions to Complexity: The Role for Pneumonia Guidelines in Precision Medicine B.E. Jones, MD, MSc, Salt Lake City, UT 2:33 Multiplex PCR to Enhance Precision in Diagnosing Pneumonia 2 D. Stolz, MD, Basel, Switzerland 2:51 Multi-Omics Approaches to Endotyping Pneumonia 3 C. Dela Cruz, MD, PhD, ATSF, New Haven, CT 3:09 Immunologic Phenotypes in Community Acquired Pneumonia 4 M.R. Menendez Villanueva, MD, Valencia, Spain 3:27 Mapping the Trajectory of Pneumonia Phenotypes Using Novel Clinical Endpoints 5 R.G. Wunderink, MD, Chicago, IL

Objectives At the conclusion of this session, the participant will be able to: • to learn new findings on lymphatics structure and function in the lung and how this is related to disease • to be able to apply knowledge on lymphatics and follicles in management of patients treated with steroids and other immune modulators • to be able to apply knowledge on lymphatics and follicles in management of patients who had undergone lung transplantation Lymphatics and lymphoid follicles are integral to the lung immune response and for processing antigens from the environment. This sessions will review the biology of the lymphatic and associated lymphoid follicle and immune responses in the lung, discuss how changes in these structures are associated with different disease phenotypes. The learner will better understand how lymphatics are linked to the immune response and appreciate these understudied structures in the lung. Chairing: J.E. Mcdonough, PhD, New Haven, CT H. Outtz Reed, MD, PhD, New York,, NY 2:15 Lymphoid Follicles in COPD: An Unanswered Question F. Polverino, MD, PhD, Houston, TX 2:30 Lymphoid Follicles: A Good Intention Turned Bad A. Yildirim, PhD, Neuherberg, Germany 2:45 The Role of Lymphatic Function in the Pathogenesis of Lung Disease H. Outtz Reed, MD, PhD, New York,, NY 3:00 Harnessing Lymphatic Transport for Drug Delivery K. Maisel, PhD, Maryland, MD 3:15 Pulmonary Lymphatic Diseases: Novel Imaging and Interventional Treatment M. Itkin, MD, Philadelphia, PA 3:30 Multiomics Approaches to Understand Lung Lymphatics and Its Role in Lymphangioleiomyomatosis M. Guo, PhD, Cincinnati, OH

CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 1.5

B86 PRECISION MEDICINE IN PNEUMONIA Assemblies on Pulmonary Infections and Tuberculosis; Critical Care 2:15 PM - 3:45 PM Walter E. Washington Convention Center Room 146 A-C (Street Level) Target Audience Pulmonary, critical care or infectious disease physicians/providers who

ATS 2023 • Washington, DC