Final-Program-ATS-2023-AP.vp

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MONDAY • MAY 22

104 Lymphoid Follicle Transcriptome Identifies Off-targeted Immune Responses in Severe COPD/ J.J. Rojas-Quintero, Houston, TX 105 Networks of Host Proteins Associate With Haemophilus Burdens and COPD Exacerbation Risks/ J. Kearley, Gaithersburg, MD 106 Intestinal Microbiota Links to Allograft Stability After Lung Transplantation: A Prospective Cohort Study/ J. Wu, Shanghai, China 107 E-cigarette Vapor Extract Has a Substantial Effect on Human Eosinophil Transcription Mediated by Propylene Glycol and Glycerin/ N. Hogan, La Jolla, CA 108 Distinct Transcriptome Networks Define Early Life Longitudinal Wheezing Phenotypes/ K. Phelan, Cincinnati, OH 109 Plasma Protein Biomarkers of Lung Function and Respiratory Diseases/ M. Aggarwal, Framingham, MA 110 Heterogeneity in Neutrophil Transcriptomes During Streptococcus Pneumoniae Pneumonia Suggests Diverse Neutrophil Functions During Infection/ J.C. Gomez, Chapel Hill, NC 111 Longitudinal Single-cell Immune Profiling Using a Model of the Restrictive Phenotype of Chronic Lung Allograft Dysfunction Reveal Diverse B and T Cell Responses/ A.P. Mclinden, Ann Arbor, MI 112 Proteomic Analysis of IPF Patient Serum Using the Somascan ® Platform Identifies Potential Biomarkers of Disease and Outcome/ M. Nandakumar, Foster City, CA 113 Overlap Between COPD Genetic Association Results and Transcriptional Quantitative Trait Loci/ A. Saferali, Boston, MA 114 Genetically Driven Splicing of MTCL1 in Lung Tissue and Airway Epithelial Cells Is Associated With COPD Case Control Status/ A. Saferali, Boston, MA 115 Metabolites Characteristics of Lower Respiratory Tract in Patients With Pneumoconiosis/ D. Jine, Kunming, China 116 Study of the Methylation Profile of Eosinophils Isolated From the Blood of People With Asthma/ R. Dionne-Gagné, Saguenay, Canada 117 Impdh Polymorphisms Are Associated With Increased Risk of Neutropenia in Transplant Patients Receiving Mycophenolic Acid/ L.K. Tague, Saint Louis, MO 118 Association of ORMDL3 Polymorphisms With Disease Outcomes and Severity in Patients With Pulmonary Alveolar Proteinosis (PAP)/ F. Bonella, Essen, Germany

2:51 Large Airway Mucus Plugs in Severe Asthma Are Spatially Associated With Air Trapping and Correlate With Airflow Obstruction in Proportion to Their Effect on Airway Resistance/ B. Huang, San Francisco, CA 3:03 Quantitative CT and Computational Fluid Dynamics (CFD) Tidal Breathing Simulation Associate Baseline Regional Lung Ventilation With Bronchial Thermoplasty Response in Asthma/ D.H. Lee, Kansas City, KS 3:15 Widespread Air Trapping in Asthma Is Associated With Airway Eosinophilia and Altered Airway Behavior During Expiration/ C. Leung, San Francisco, CA 3:27 Respiratory Impedance Corresponds to Clinical Outcomes in Children With Acute Asthma Exacerbations in the Pediatric Emergency Department/ N. Navanandan, Aurora, CO 3:39 The Reduction of Airway Smooth Muscle by Bronchial Thermoplasty Stands the Test of Time/ P.-A. Gagnon, Québec, Canada 3:51 Central Airways Resistance Increases in Pregnant Women With Obstructive Sleep Apnea and Asthma/ C.D. Theroux, Providence, RI B101 OMICS STUDIES OF IMMUNE CELLS AND THE LUNG 2:15 p.m. - 4:15 p.m. Marriott Marquis Washington Marquis Ballroom, Salons 1-2 (Level M2) Poster Viewing 2:15-3:00 Discussion 3:00-4:15 Chairing: S.-Y. Liao, MD, MPH, ScD, Denver, CO D. Okin, MD, PhD, Boston, MA J. Alladina, MD, Boston, MA I.R. Konigsberg, PhD, Aurora, CO 101 Unsupervised Clustering of Sputum Transcriptomes Identifies Three COPD Exacerbation Endotypes With Differing Susceptibilities and Pathobiology/ A. Sarma, San Francisco, CA 102 The Effect of Inhaled Corticosteroid Withdrawal on the Airway Metagenome and Antimicrobial Resistance: Data From the INCOGNITO Trial/ H.R. Keir, Dundee, United Kingdom 103 Association of Gut Microbiome Changes With Chronic BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION

Inflammation and Pulmonary Emphysema in a Nonhuman Primate Model of SIV Infection/ S. Qin, Pittsburgh, PA

ATS 2023 • Washington, DC