Final-Program-ATS-2023-AP.vp

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MONDAY • MAY 22

720 Using Single Cell Sequencing to Understand Treatment Response to Anti-IL33 Treatment in Chronic Obstructive Pulmonary Disease (COPD)/ A. Faiz, Ultimo, Australia 721 Maple: A Novel Computational Tool for Multi-Sample Spatial Transcriptomics Data Analysis/ D. Chung, Columbus, OH 722 Role of Sphingosine-1-Phosphate in Stress Autophagy Induced by Cigarette Smoke Exposure in Lung Microvascular Endothelial Cells/ B. Dubois, Denver, CO 723 Dissecting the Role of Endothelial Derived Leucine Rich Alpha-2-Glycoprotein 1 (LRG1) In the Pathogenesis of Emphysema/ A.C. Racanelli, NY, NY

706 Mitochondria-to-Nucleus Retrograde Signaling Via Mitochondrial DNA Encoded Non-coding RNA Regulates Mitochondrial Bioenergetics/ T.L. Joseph Mathuram, Buffalo, NY 707 Metformin Protects Against Cigarette Smoke Induced Small Airway Fibrosis by Reducing Airway Muscle Sarcoglycan Assembly/ J.J. Rojas-Quintero, Houston, TX 708 Metformin Protects Lung Epithelial Cells Against Cigarette Smoke-Induced Lipo-Peroxidation/ J.J. Rojas-Quintero, Houston, TX 709 Metformin Rescues Cigarette Smoke-Induced Mucociliary Dysfunction Via P38 Signaling in Airway Epithelial Cells of COPD Donors/ N. Baumlin, Kansas City, KS 710 p 16INK4a Deletion Exacerbates Lung Disease Progression Induced by Low-dose Exposure to Environmental Tobacco Smoke/ T. Muthumalage, Rochester, NY 711 Pulmonary Delivery of PRS-400 Anti-Jagged-1 Anticalin Proteins Reduce Inflammation-driven Goblet Cell Metaplasia and Mucus Hypersecretion In Vivo/ M. Hagner, Hallbergmoos, Germany 712 MCTR3 Mitigates Inflammation Induced by Pro-inflammatory Stimuli in Small Airway Epithelial Cells Through Distinct Changes in Micro RNA Expression/ Y.P.A. Myo, Richmond, VA 713 Network Medicine Approaches Reveal Sex-biased Regulation of Extracellular Matrix Pathway in COPD/ C.M. Lopes-Ramos, Boston, MA 714 Membrane-bound MUC1 Mucin Mediates Cigarette Smoke-induced Aberrant EGFR Activation and Airway Epithelial Remodeling In Vivo/ K. Kato, Atlanta, GA 715 E-cigarette Aerosols of Propylene Glycol Impair BK Channel Conductance and Mucociliary Function/ M. Kim, Kansas City, KS 716 Cigarette Smoke Exacerbates Bleomycin-induced Lung Injury and Collagen Deposition Via Lysyl Oxidase-dependent Mechanism in Mice/ Q. Wang, Rochester, NY 717 Anti-CELA1 KF4 Antibody Inhibits Stretch-inducible Elastin Remodeling in Human Lung And Preserves Lung Structure in PPE, Cigarette Smoke, and Alpha-1 Antitrypsin Deficient Emphysema Models/ B.M. Varisco, Cincinnati, OH 718 Lobar Specific Transcriptome of Combined Pulmonary Fibrosis and Emphysema Reveals Unexpected Contributions of Emphysema and Pulmonary Fibrosis Signatures/ F. Darawshy, New york, NY 719 Mapping the Effect of Cigarette Smoke (CS) on the Lung Lymphatic Endothelium/ A. Trivedi, New York, NY

BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION

B108 IMMUNE CELLS TO THE RESCUE IN LUNG INJURY 2:15 p.m. - 4:15 p.m.

Walter E. Washington Convention Center Room 151 A (Street Level)

Poster Viewing

2:15-3:00 3:00-4:15

Discussion

Chairing: B.D. Kraft, MD, ATSF, FCCP, Saint Louis, MO B.D. Singer, MD, ATSF, Chicago, IL S.J. Denstaedt, MD, Ann Arbor, MI 401 Adoptive Transfer of Monocytes Protects Against Lung Injury by Connexin 43 Enrichment in Alveoli/ G.A. Gusarova, New York, NY 402 Multi-dimensional Profiling of Alveolar T Cell Responses During Severe Pneumonia/ L. Morales-Nebreda, Chicago, IL 403 Systematic Comparison of Murine Models of Chronic Lung Allograft Dysfunction/ M. Bueno, Pittsburgh, PA 404 Secondary Lymphoid Organ Repopulation With Cytotoxic Tissue Resident Memory T Cells After Lung Transplantation/ K. Moghbeli, Pittsburgh, PA 405 Impaired PPAR g Activation Exacerbates Infection-Induced Lung Injury/ J.L. Larson-Casey, Birmingham, AL 406 Supersurvivors After Lung Transplantation - Do Macrophages Play a Protective Role?/ M.P. Kuehnel, Hannover, Germany 407 Neonatal Hyperoxia Induces Alveolar Macrophage

Dysfunction And Dysregulated Type 1 Interferon Responses In Experimental Bronchopulmonary Dysplasia/ T.X. Cui, Ann Arbor, MI

ATS 2023 • Washington, DC