Final-Program-ATS-2023-AP.vp

MONDAY • MAY 22

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408 Complement-induced Local Inflammatory Priming and Upregulation of Pro-fibrotic Signaling Pathways in Mesenchymal Stromal Cells Derived From Lung Transplant Patients/ R. Vittal, Ann Arbor, MI 409 Effect of Microbiome and Diet on Alveolar Macrophages and Lung Injury Following Ischemia Reperfusion (IR) Injury/ A. Prakash, San Francisco, CA 410 Alveolar Epithelial Cells Mitigate Neutrophilic Inflammation in Acute Lung Injury Through Regulating Mitochondrial Fatty Acid Oxidation/ K.-P. Chung, Taipei, Taiwan 411 Inflammatory Effects of Sleep Fragmentation in Mice With Acute Lung Injury/ H. Ediriweera, Miami, FL 412 Regulation of Mesenchymal Cell Fate by Transfer of Active Gasdermin-D Via Monocyte-derived Extracellular Vesicles/ A. Sarkar, Columbus, OH 413 Proteomic Analysis of Heat-moisture Exchange (HME) Filter Fluid Reveals Differences Between Donor Lungs Accepted or Declined for Transplantation/ C.M. Shaver, Nashville, TN 414 Functional Heterogeneity of Neutrophils in the Lungs During Infection/ L. Ghimire, Boston, MA 415 TRMT1 Preserves Transfer RNA Integrity and Macrophage Viability During Bacterial Infection/ J.S. Bednash, Columbus, OH 416 Ventilator-Induced Lung Injury Promotes Inflammation Within the Pleural Cavity in a Mouse Model/ R.F. Baldi, London, United Kingdom 417 TRMT1 Is Vital for Macrophage Cytokine Responses to Infection/ J.D. Londino, Columbus, OH 418 Sex-specific Transcriptome Profiles and Cytokine Responses in Cystic Fibrosis Monocytes/ H. Yin, New Haven, CT 419 MALAT1 Modulates HIV Immune Response Through MiR-150-5p/SOCS1 in Macrophages/ Z. Yuan, Omaha, NE 420 Two Pore Potassium Channel TREK-1 Regulates K+ Efflux and Membrane Potential in Macrophages/ C.N. Immanuel, Austin, TX 421 Increased Inflammation Protects From Lung Fibrosis in Siglec F Knock Out Mice/ M. Orlov, Aurora, CO 422 Antenatal Corticosteroids Drive Maturation of the Epithelial and Endothelial Components of the Developing Primate Lung and Protect From Inflammatory Endothelial Injury/ W. Zacharias, Cincinnati, OH 423 LPS Treatment Enhances the Immunomodulatory Effect of Mesenchymal Stromal Cells-derived Extracellular Vesicles/ A. Areny-Balagueró, Sabadell, Spain

BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION

B109 BIOMARKERS, GENETICS, AND OMICS IN SLEEP DISORDERED BREATHING 2:15 p.m. - 4:15 p.m. Walter E. Washington Convention Center Room 151 B (Street Level) Poster Viewing 2:15-3:00 Discussion 3:00-4:15 Chairing: B.E. Cade, PhD, Boston, MA C. Caballero, MD, PhD, Seville, Spain D. Gozal, MD, MBA, ATSF, Columbia, MO A. Alfini, Bethesda, MD A. Gileles-Hillel, MD, Jerusalem, Israel 501 Circulating Plasma Exosomal Cargo in Long Term Adherence of Obstructive Sleep Apnea (OSA): Multi-omics/ A. Khalyfa, Columbia, MO 502 Genetic Ablation of P16 Improves Cellular Senescence and Insulin Sensitivity in a Murine Model of Sleep Apnea/ A. Khalyfa, Columbia, MO 503 Inflammation Biomarkers in COPD-OSA Overlap Syndrome/ A. Sanchez Azofra, La Jolla, CA 504 Endothelial Cell-specific Deletion of Plasminogen Activator Inhibtor-1 Ameliorates Coronary Artery Function Under Intermittent Hypoxia Conditions/ M. Badran, Columbia, MO 505 P16-mediated Senescence in Vascular Dysfunction in Murine Models of Obstructive Sleep Apnea/ K. Cataldo, Columbia, MO 506 Epigenetic Alterations and Accelerated Biological Aging Associated With Impaired Ovarian Capacity in a Murine Model of OSA/ R. Cortese, Columbia, MO 507 The Effects of Sleep Deprivation on a Stuttering Mouse Model/ A. Turk, Bethesda, MD 508 Effect of Obesity in Combined Sustained and Intermittent (Overlap) Hypoxia/ M. Hackbarth, La Jolla, CA 509 Impaired Intracellular Cholesterol Trafficking Promotes Endothelial Inflammation Observed in Sleep Apnea/ V.K. Shah, New York, NY 510 Physical Activity Attenuates the Impact of Genetic Predisposition to Obesity on Risk of Obstructive Sleep Apnea: Results From Three Prospective US Cohorts/ T. Huang, Boston, MA

ATS 2023 • Washington, DC