Final-Program-ATS-2023-AP.vp

TUESDAY • MAY 23

219

• apply expert-consensus mitigation strategies for bias to improve the quality of clinical care Risk and disease prediction tools are common in clinical practice. They are vital to high-quality care—simplifying complexity in evidence-based fashion. Yet, despite being used everyday use, many tools are now recognized to be racially biased, skewing clinical judgments, to contribute to worse outcomes for minoritized populations. This session brings together experts in health equity and clinical/prediction testing to discuss this manifestation of structural racism in pulmonary and critical care medicine. Attendees will learn about real world examples of biased tools used every day in our field, build a framework for understanding how biased tools emerge, and review mitigation strategies. Chairing: A.D. Baugh, MD, San Francisco, CA D.C. Ashana, MD, MBA, MS, Durham, NC T.S. Valley, MD, MSc, Ann Arbor, MI 9:00 Introduction A.D. Baugh, MD, San Francisco, CA 9:05 Color-Blind or Context Blind? Understanding Race in Pulmonary Function Testing A.D. Baugh, MD, San Francisco, CA 9:16 Hold Your Breath: The Journey to an Equitable Pulse Oximeter T.S. Valley, MD, MSc, Ann Arbor, MI 9:27 When Technology Imitates Life: How Bias Manifests in Risk Prediction and Artificial Intelligence D.C. Ashana, MD, MBA, MS, Durham, NC 9:38 Shortcomings of Standard Cystic Fibrosis Screening Tests Among Individuals of African Ancestry J.L. Taylor-Cousar, MD, MSc, ATSF, Denver, CO 9:49 Unequal Risk: Modifying Lung Cancer Screening Guidelines 10:00 The Bias of Machines L.A. Perine, MBA, College Park, MD 10:11 Summary D.C. Ashana, MD, MBA, MS, Durham, NC 10:16 Discussion T.S. Valley, MD, MSc, Ann Arbor, MI

BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 1.5

C6 DISPARITIES IN RESPIRATORY GENOMICS RESEARCH: STRATEGIES TO ADVANCE SCIENCE AND CLINICAL CARE Assemblies on Allergy, Immunology and Inflammation; Environmental, Occupational and Population Health; Section on Genetics and Genomics 9:00 AM - 10:30 AM Marriott Marquis Washington Marquis Ballroom Salon 6 (Level M2) Target Audience Everyone in medicine and science has a sphere of influence that could contribute to mitigating health disparities -trainees, clinical faculty, research faculty , healthcare staff, research staff, and administration. Objectives At the conclusion of this session, the participant will be able to: • gain awareness of current race- and sex-specific health inequities in complex lung diseases, the importance of addressing underrepresentation in genomic studies, and implications on the development of polygenic risk scores for disease and traits • awareness of common misconceptions as it relates to minorities and Mendelian orphan lung diseases, with a focus on cystic fibrosis, how this can impair diagnosis, prognosis, and access to precision modulator therapies, and next best steps forward • address scientific & clinical issues in genomics as they relate to health disparities in the context of genetic epidemiology, development of predictive genomic profiles, multi-omics approaches, gene-by-environment interactions, & clinical translation Advances in genomic technologies have primarily applied to European descent whites with one-to-two percent of African descent minorities and Hispanics included in genetic studies of disease. These underrepresented groups experience a disproportionate burden of respiratory disease and have an underappreciated risk for orphan diseases traditionally considered to be white-only, such as cystic fibrosis. In addition, a minority of genomic studies address differences of respiratory disease risk and severity specific to sex. This workshop will address scientifically and clinically relevant issues in genomics as they relate to health disparities from the context of genetic epidemiology, the development of predictive genomic profiles, multi-omics approaches, gene-by-environment interactions, and clinical translation. Chairing: A. Souquette, PhD, Memphis, TN

V.E. Ortega, MD, PhD, ATSF, Scottsdale, AZ J. Pantaleón García, BS, MD, Houston, TX D.L. Demeo, MD, Boston, MA

9:00 Introduction

A. Souquette, PhD, Memphis, TN

ATS 2023 • Washington, DC