Final-Program-ATS-2023-AP.vp

232

TUESDAY • MAY 23

110 TMEM100, a Lung-specific Endothelium Gene/ B. Liu, Phoenix, AZ 111 Murine Model of Phenylhydrazine-Induced Chronic Hemolysis Combined With Hypoxia Leads to Development of Severe Pulmonary Hypertension/ J. Gonzales, Chicago, IL 112 Mesenchymal Stem Cells-derived Microparticles Preserve RUNX1 Stability During the Intercellular Communication Leading to Endothelial Cell Recovery and Proliferation After Injury/ S.A. Predescu, Chicago, IL 113 DLL4/NOTCH1 Induces PPPAR g , Suppressing AKT and the Proliferative, Apoptosis Resistant Phenotype of BMPR2-silenced Pulmonary Artery Endothelial Cells/ K. Awad, Bethesda, MD 114 Intrinsic Deficiency of PAI-1 in Human Pulmonary Proliferation and Induces Spontaneous Pulmonary Hypertension in Mice/ V. Stepanova, Philadelphia, PA 115 Mutation of Akt1 Renders Pulmonary Hypertension Resistant Phenotype With Inhibited EndMT/ M. Valuparampil Varghese, Tucson, AZ 116 Small Leucine-Rich Proteoglycan Asporin Represses Smooth Muscle Cell Proliferation and Regulates Pulmonary Hypertension Development/ L. Medzikovic, Los Angeles, CA 117 Stretch Receptors Attenuate the Prothrombotic Transformation of the Endothelium/ K. Sack, Boston, MA 118 RUNX1 Mediates Pulmonary Hypertension Associated With Impaired SOX17 Expression/ J.R. Klinger, Providence, RI 119 CD39-bearing Extracellular Vesicles Regulate Pulmonary Thrombosis in Sickle Cell Disease/ T. Brzoska, Pittsburgh, PA 120 Dysregulation of the Cytosolic Double Stranded RNA Receptor System and Interleukin-10 Signaling in Endothelial Dysfunction in Pulmonary Arterial Hypertension/ G.S. Newcomb, Columbus, OH 121 Vps34 Activation Is Pulmonary Vascular Smooth Muscle Cell-specific and Akt-dependent in Pulmonary Arterial Hypertension/ Y. Shen, Davis, CA 122 Aberrant Pulmonary Endothelial Cell Angiogenesis Driven by Constitutive Mesenchymal mTOR Activation/ S. Lin, Philadelphia, PA 123 Chitinase 3-like-1 Protein Contributes to the Development of Pulmonary Vascular Remodeling in Pulmonary Hypertension/ C. Norbrun, Providence, RI Arterial Smooth Muscle Cells From Pulmonary Artery Hypertension (PAH) Patients Drives UPA-dependent Cell

622 Are Italian Pediatric Educational Programs Suitable to Treat Obstructive Sleep Apnea?/ L.M. Nosetti, Varese, Italy

BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION

C26

UNRAVELING THE GORDIAN KNOT: MULTI-DIMENSIONAL -OMICs AND SIGNALING MOTIFS IN PULMONARY VASCULAR DISEASE

9:00 a.m. - 11:00 a.m.

Marriott Marquis Washington Marquis Ballroom, Salons 1-2 (Level M2)

Poster Viewing

9:00-9:45 9:45-11:00

Discussion

Chairing: T.V. Kudryashova, PhD, Davis, CA Z. Dai, PhD, Phoenix, AZ I. Al Ghouleh, PhD, Pittsburgh, PA 101 Unraveling the Epigenetic Mechanisms as Potential Driver of Female Predominance in Pulmonary Arterial Hypertension/ A.K. Wawrzen, Graz, Austria 102 Proteomic Signature of MicroRNA-126 Targets in COPD Individuals With Putative Pulmonary Hypertension/ K. Goel, Los Angeles, CA 103 Endothelial Specific CARMIL1 Knockdown Exacerbates In Vivo Lung Injury/ C. Humpal, Chicago, IL 104 Single Cell Transcriptomic Analysis Reveals Cooperation Between Activated Arterial ECs and Acta2+ Pericytes in Complex Arterial Remodeling in Pulmonary Arterial Hypertension/ N.D. Cober, Ottawa, Canada 105 MicroRNA Regulation of the 3’ Untranslated Region of COL18a1 in Pulmonary Arterial Hypertension/ T. Tuhy, Baltimore, MD 106 Direct Delivery of MicroRNA-96 to the Lungs of Sugen/Hypoxic Rats Reduces an Estrogen Metabolizing Enzyme and Fibrotic Markers Gene Expression in the Lungs/ H. Labazi, Glasgow, United Kingdom 107 Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery/ E.P. Manning, New Haven, CT 108 Neonatal Hyperoxia Causes Vascular Smooth Muscle Specific Transcriptomic Changes and Pulmonary Hypertension/ D.T. Dinh, Palo Alto, CA 109 Loss of Tet2 Associated Clonal Hematopoiesis Contributes to Hypoxia-induced Pulmonary Hypertension in a Mouse Mode/ S.Y. Farha, Cleveland, OH

ATS 2023 • Washington, DC