Final-Program-ATS-2023-AP.vp

270

TUESDAY • MAY 23

P378 RNA Sequencing Analysis: Exploring Genomic Effects of Safe Inhaled Alkaline Buffer Optate/ I.A. Daniels, Indianapolis, IN P379 Acidity Lowers the Purinergic Receptor Response by Protonating ATP/ I. Thornell, Iowa City, IA P380 RLS-0071, A Novel Dual-targeting Anti-inflammatory Agent, Demonstrates Proof of Mechanism in a Phase 1b Inhaled LPS Study Significantly Reducing Lung Neutrophils/ J.M. Hohlfeld, Hannover, Germany P381 Activation of Adam12-SDC4 and CCL22-CCR4 Pathways in the Airway in Asthma/ G.L. Chupp, New Haven, CT P382 Role of Fatty Acid Oxidation in Obesity Associated Acute Lung Injury/ E. Kallinos, New York, NY P383 Evaluating Pp2a B Subunits Ppp2r2b, Ppp2r2c, Ppp2r3a, and Ppp2r5d Cytokine Expression in Human Bronchiole Small Airway Epithelial Cells Smoke Damage Models/ O. Ukponmwan, Brooklyn, NY P384 Novel Fully Primary Human Airway Epithelium-Alveolar Macrophages In Vitro Co-cultures Models to Study Host Pathogen Interactions/ X.-Y. Huang, Plan Les Ouates, Switzerland P385 Regulation of Forkhead Box K2 (foxk2) By the E3-ligase F-box Only Protein 24 (fbxo24) Leads to Its Ubiquitination and Degradation in Lung Epithelia/ R. Elmergawy, Columbus, OH P386 Lung Extracellular Matrix Hydrogels - Derived Nanoparticles Contribute to Epithelial Lung Repair/ A. Ulldemolins, Barcelona, Spain P387 Development of Fully Primary Human 3D Alveolar Model (AlveolAir™)/ C. Ferreira Lopes, Plan-les-Ouates, Switzerland P388 All Cells That Wander in Monocle Are Not Lost: Trajectory Pathway Analysis of Airway Basal Cell After Chemical Inhalation Exposures/ M.D. Mcgraw, Rochester, NY

P391 Association of Hair Follicle Gene Expression With Airway Lumen Size and Wall Area on CT in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)/ K. Buschur, New York, NY P392 Live Biotherapeutic Performs at Par With Steroids in Reducing Neutrophilic Inflammation in Models of COPD/ C.V. Lal, Birmingham, AL P393 A TP53 Genotype Affects Mucin Gene Expression and Survival of Female Embryos/ M. Rahman, Boston, MA P394 Loss of Cofilin-1 in an Unjammed Airway Epithelia of Chronic Obstructive Pulmonary Disease (COPD) Causes Mitochondrial Dysfunction/ B. Ghosh, Baltimore, MD P395 Targeting S100A9 Signaling Reduces Lung Cell Death and Inflammation in Alpha-1 Antitrypsin Deficiency/ B. Jundi, Brooklyn, NY P396 Nebulized Platelet-derived Extracellular Vesicles Attenuate Cigarette Smoke-induced Inflammation in a Murine Model/ A. Alarcon-Calderon, Rochester, MN P397 Lectin Complement Pathway Activation Is Necessary for Cigarette Smoke Induced Murine Lung Injury/ I. Echelman, Denver, CO P398 Novel Polycationic Glycopolymer Augments In Vitro Mucociliary Transport Rate in COPD Cell Cultures/ K. Vijaykumar, Birmingham, AL P399 Effects of Chronic Box Mod E-cigarette Aerosol Exposures on Organ Damage and Gene Expression in Mice/ H. Chang, La Jolla, CA P400 The Vascular Antiremodeling Effects of the Soluble Guanylate Cyclase Stimulator Bay 63-2521 Are Mediated by Inhibition of MAPK Pathways in Pulmonary Artery Smooth Muscle Cells/ A. Bosacoma Armora, Madrid, Spain P401 Lipid Peroxidation and Ferroptosis as Candidate Pathways of Heated Tobacco Product Toxicity in the Lung/ K. Ganguly, Stockholm, Sweden P402 Tozorakimab (Anti-IL-33) Rebalances COPD Epithelium Enhancing Club Cell Activities and Reshaping Viral Responses/ X. Romero Ros, Cambridge, United Kingdom P403 Characterizing the Role of Nephronectin in a Mouse Model of Emphysema/ M. Jasicki, Madison, WI P404 Monocyte Subsets and Their Mitochondrial Dynamics Are Disrupted in Alpha-1-Antitrypsin Deficiency/ E. Leacy, Dublin, Ireland P405 CEACAM6 as a Determinant of Lung Epithelial Cell Fate Upon Cigarette Smoke Exposure/ C.-Y. Wu, Giessen, Germany P406 Role of TGF-ß in Cellular Senescence and Inflammaging by Microrna Mediated Gene Silencing/ S. Chinnapaiyan, Miami, FL

BASIC • TRANSLATIONAL THEMATIC POSTER SESSION

C69

PRECLINICAL COPD MODELS: IN VITRO, EX VIVO, IN VIVO

9:00 a.m. - 4:15 p.m.

Walter E. Washington Convention Center Area D, Hall C (Lower Level)

Viewing: Posters will be on display for entire session

11:30-1:15

Discussion: 11:30-12:15 authors will be present for individual discussion

12:15-1:15 authors will be present for discussionwith assigned facilitators.

ATS 2023 • Washington, DC