Final-Program-ATS-2023-AP.vp

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TUESDAY • MAY 23

412 Paired Related Homeobox 2 (Prrx2) Contributes to Pulmonary Vascular Remodeling and PH by Targeting IL-6/stat3 Signaling in Pulmonary Artery Smooth Muscle Cells/ T. Chen, Chicago, IL 413 Cardiac Macrophages Are the Primary Complement C3a Receptor (C3aR) Expressing Cells in the Rat Myocardium and Remain Stable in Late Sugen Hypoxia Pulmonary Hypertension/ S. Gu, Aurora, CO 414 Local Production and Activation of Complements by the Adventitial Fibroblast Play a Crucial Role in Pulmonary Hypertension/ R. Prasad, Aurora, CO 415 TLR7 Activation Induces Autoimmune Vasculopathy and Causes Severe Pulmonary Arterial Hypertension/ C. Chen, London, United Kingdom 416 SIRT3 Affects Adventitial Fibroblasts Phenotype in Pulmonary Hypertension Through Regulation of Mitochondrial Function/ M. Li, Aurora, CO 417 BMP-Responsive Transcription Factor Expression Is Increased in Advanced PAH Lung Lesions/ A.M. Andruska, Palo Alto, CA 418 Mitochondrial DNA Copy Numbers Reflect Different Suites of Adaptations in Two East African Highland Populations/ A.J. Janocha, Cleveland, OH 419 Human Pulmonary Artery Endothelial Cells Isolated From Patients With Pulmonary Hypertension Exhibit Heterogeneous Sensitivity to Mechanical Sensing/ S. Subedi Paudel, Mobile, AL 420 Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary Artery/ E.P. Manning, New Haven, CT 421 Transaortic Constriction Improves Ventricular Performance in Mice With Right Ventricular Pressure Overload/ M.J. Lucero, Aurora, CO 422 Epigenetic Mechanisms Mediate Cytochrome P450 1A1 Expression and Lung Endothelial Injury Caused by MRSA/ L. Meliton, Chicago, IL 423 Oxidized Cell-free Hemoglobin and Low-density Lipoprotein Contribute to Lung Microvascular Endothelial Barrier Dysfunction and Poor Outcomes During Sepsis/ J.E. Meegan, Nashville, TN 424 Role of Inflammatory Monocytes in Hypoxic Pulmonary Hypertension/ R. Kumar, San Francisco, CA 425 IRG1/Itaconate Axis as an Immunometabolic Regulator of Pulmonary Hypertension/ G. Hesami, Bad Nauheim, Germany

BASIC • TRANSLATIONAL POSTER DISCUSSION SESSION

C107 AT THE CROSSROADS OF DISEASE: METABOLIC AND INFLAMMATORY DRIVERS IN PULMONARY VASCULAR DISEASE 2:15 p.m. - 4:15 p.m. Walter E. Washington Convention Center Room 151 A (Street Level) Poster Viewing 2:15-3:00 Discussion 3:00-4:15 Chairing: M.R. Maclean, PhD, ATSF, Glasgow, United Kingdom L. Zhao, PhD, MD, London, United Kingdom L. Zhang, PhD, Pittsburgh, PA 401 2-HOBA Resolves Metabolic Problems in Two Pulmonary Hypertension Models/ J.D. West, Nashville, TN 402 Low CYP1B1 Drives Pulmonary Arterial Hypertension Through Ubiquitination of PPARG/ J.D. West, Nashville, TN 403 Increased MFGE8 and Decreased ApoA5 Associated With RV Lipotoxicity and Insulin Resistance/ M. Talati, Nashville, TN 404 17ß-estradiol Regulates Angiogenesis and Metabolism in Cultured Human Cardiac Microvascular Endothelial Cells and in the Right Ventricle of Rats With Experimental Pulmonary Hypertension/ S. Bousseau, Denver, CO 405 Frataxin Deficiency Is a Shared Driver of Endothelial Metabolic Dysfunction and Senescence Relevant to Pulmonary Hypertension/ M.P. Mehta, Pittsburgh, PA 406 Arginine Metabolism Changes Hypoxia Responses in Mice Deficient for Arginase-2 (ARG2)/ W. Xu, Cleveland, OH 407 Role for Transglutaminase 2 in Interleukin 6 and Glycolysis Mediated Cardiopulmonary Fibrogenesis/ Y. Sharma, Boston, MA 408 Aging Mediated Cardiopulmonary Remodeling in Senescent Mouse Models/ Y. Sharma, Boston, MA 409 Damaged Mitochondria Contribute to Hyperoxia-induced Impaired Angiogenesis and Lung Injury in Neonatal Mice/ H. Yao, Providence, RI 410 The Critical Role of CD206+ Macrophages in Contributing to Severe Pulmonary Arterial Hypertension and Obliterative Vascular Remodeling/ J. Dai, Chicago, IL 411 The Lectin Complement Pathway Contributes to Schistosoma-induced Pulmonary Hypertension/ C. Mickael, Aurora, CO

ATS 2023 • Washington, DC