Final-Program-ATS-2023-AP.vp

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TUESDAY • MAY 23

1020 Contributions of MUC5B to Mucociliary Clearance Using A Genetically Modified Pig Model/ G.S. Romano Ibarra, Iowa City, IA 1021 Use of Bioengineered Rat Lungs for Novel Ex Vivo Human Lung Cancer Models/ S. Mizoguchi, Nagasaki, Japan 1022 A Novel 3D Spring Network Representation of Alveolar Geometry Combined With Agent Based Modeling to Predict Ventilation Heterogeneity in Pulmonary Fibrosis/ J.K. Hall, Boston, MA 1023 Modeling the Stiffness of Healthy and Diseased Lung Tissues by a Gel-Coated Air-Liquid-Interface Culture System With Tunable Substrate Stiffness/ Z. He, Charlottesville, VA 1024 Respiratory Dysfunction in TDP-43 A315T Mice-Mouse Model of Amyotrophic Lateral Sclerosis/ D. Biswas, Durham, NC 1025 The Relaxation Effect of Pitavastatin on Human Airway Smooth Muscle Cells: A Role for Acute F-actin Disruption/ A.A. Zeki, Davis, CA BASIC • BEHAVIORAL • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION C110 ADVANCED SIGNAL ANALYSIS: NEW DIAGNOSTICS AND PHYSIOLOGIC INSIGHTS FOR SDB 2:15 p.m. - 4:15 p.m. Walter E. Washington Convention Center Room 144 A-C (Street Level) Poster Viewing 2:15-3:00 Discussion 3:00-4:15 Chairing: A. Parekh, PhD, New York, NY A. Yadollahi, PhD, Toronto, Canada C.D. Turnbull, BM BCH, PhD, Oxford, United Kingdom M. Yamauchi, MD, PhD, ATSF, Kashihara, Japan 301 Identifying Central Versus Obstructive Sleep Apnea in Patients With Heart Failure/ R.M. Alex, Boston, MA 302 Pathophysiological Mechanisms Underlying Spontaneous Stable Breathing in OSA/ L. Gell, Boston, MA 303 Hypoxic Burden Based on Automatically Identified Desaturations Predicts Cardiovascular Mortality/ N. Esmaeili, Boston, MA 304 Prevalence, Pathophysiology, and Predictors of Expiratory Palatal Prolapse in Sleep Apnea/ J. Sumner, Boston, MA

1004 Mitochondrial Dysfunction Associated With Aging Contributes to Slowed Cilia Beat Frequency/ K.L. Bailey, Omaha, NE 1005 The Secretome of Pulmonary Microvascular Endothelial Cells Supports Alveolar Epithelial Growth/ L. Van Der Koog, Groningen, Netherlands 1006 Utilizing Human Precision-cut Lung Slices and a Neonatal Mouse Model to Study the Respiratory Syncytial Virus Infection-induced Airway Contractile Deregulation in Early Life/ Y. Bai, Boston, MA 1007 Optogenetics Shines Light on Nerve-mediated Airway Hyperreactivity/ A.B. Pierce, Portland, OR 1008 Muc5b Mediates Antiviral Immunity and Airway Hyperresponsiveness During Parainfluenza Virus Infection/ J.M. Kornfield, Portland, OR 1009 Airway Eosinophils Modulate Purinergic Receptor P2X 3 Expression/ E.J. Mize, Portland, OR 1010 Cough-induced Mitochondrial Mechanotransduction in Type II Alveolar Epithelial Cells/ B. Suki, Boston, MA 1011 Piezo Channels Modulate Extracellular Matrix Remodeling in Developing Human Airway Smooth Muscle Cells/ E.Y. Zhang, Rochester, MN 1012 Effects of Sulfur Dioxide Inhalation Exposure on Cardiopulmonary System/ S.S. Gutor, Nashville, TN 1013 Targeting Glutathione and Ferroptosis With Hydrogen Sulfide Alleviates Effects of Oxygen on Developing ASM/ C.M. Bartman, Rochester, MN 1014 KISS1 Receptor Knockout Exacerbate Airway Hyperreactivity and Remodeling in a Mouse Model of Allergic Asthma/ N.S. Ambhore, Fargo, ND 1015 Rhinovirus C (RVC) Infection Induces a Remodeling Signature and Decreases Bronchodilator Responsiveness/ C. Spector, New Brunswick, NJ 1016 Development of a 3D Bioprinted Airway Smooth Muscle Model for Manipulating Structure and Measuring Contraction/ A.R. West, Winnipeg, Canada 1017 Effect of TNF a and IFN g on Chromatin Accessibility in Human Airway Smooth Muscle Cells/ A.S. Ruwanpathirana, Columbus, OH 1018 During the Epithelial Unjamming Transition of the

Pseudostratified Bronchial Epithelium, Basal Stem Cells and Their Stress Fibers Remodel/ T. Phung, Boston, MA

1019 Developing an In Vitro Model of Sensory Neurons

Differentiated From Human Pluripotent Stem Cells for the Study of Neuroplasticity/ C. Koster, Groningen, Netherlands

ATS 2023 • Washington, DC