Final-Program-ATS-2023-AP.vp

WEDNESDAY • MAY 24

307

Target Audience Health care providers, translational and clinical science researchers, trainees, advanced healthcare practitioners Objectives At the conclusion of this session, the participant will be able to: • to understand the cellular effects of obesity-mediated complications on the lung • to understand the contribution of obesity-related metabolic complications and that of therapeutics targeted to these metabolic complications to asthma outcomes • to understand the contribution of oxidative and nitrosative stress on obesity-related asthma and the dietary interventions to ameliorate these effects Obesity-related asthma is a well-established distinct asthma phenotype that is poorly responsive to current asthma therapeutic approaches. The lack of responsiveness to medications highlights the need to identify alternative management strategies. This symposium will discuss breakthrough findings over the past 2-3 years on biologic mechanisms underlying obesity-related asthma that have directly informed therapeutic approaches distinct from traditional asthma management. Chairing: D. Rastogi, MBBS, MS, ATSF, Washington, DC F. Holguin, MD, MPH, Aurora, CO 8:00 The Devil Is in the Detail: Exploring the Cellular Effects of Obesity-Mediated Complications on Obesity-Related Asthma J.L. Ingram, PhD, ATSF, Durham, NC 8:15 Discussion 8:18 Are Immune Perturbations Associated With Obesity-Related Asthma Ready for Prime Time Therapeutics? D. Rastogi, MBBS, MS, ATSF, Washington, DC 8:33 Discussion 8:36 Is Obesity-Related Asthma a Bystander to Benefit From Treatment Strategies for Obesity-Mediated Metabolic Perturbations A.E. Dixon, MA, BM BCH, ATSF, Burlington, VT 8:51 Discussion 8:54 Can Dietary Supplements Be Repurposed to Address the Contribution of Oxidative Stress to Obesity-Related Asthma F. Holguin, MD, MPH, Aurora, CO 9:09 Discussion 9:12 The Role of Nitrosative Stress in Obesity-Related Asthma: A New Arena for Therapeutic Development L.G. Que, MD, Durham, NC 9:27 Discussion

• develop a comprehensive framework of best buy interventions that mitigate risk factors and reduce risk for the development of chronic respiratory diseases or aid in Chronic respiratory diseases are a significant but neglected public health problem in low- and middle-income countries. Moreover, current best buy interventions recommended by the World Health Organization are limited: they principally consist of inhaled bronchodilator therapy for symptom management and mitigation of household air pollution. Yet there are opportunities for primary and secondary prevention that could help both reduce the development of chronic respiratory diseases and improve management. This session aims to identify current unmet needs for chronic respiratory diseases in low- and middle-income countries and identify other potential best buy interventions that can improve diagnosis and management of chronic respiratory diseases. Chairing: J. Hurst, MD, London, United Kingdom W. Checkley, MD, PhD, Baltimore, MD O.B. Ozoh, MBBS, ATSF, MSc, Lagos, Nigeria 8:00 The Burden of Chronic Respiratory Diseases in Low- and Middle-Income Countries and Unmet Needs for their Diagnosis and Management R. Van Zyl Smit, MBchB, PhD, ATSF, Cape Town, South Africa 8:20 An Overview of Best Buy Interventions Recommended by the World Health Organization for the Diagnosis and Management of Chronic Respiratory Diseases. S. Rylance, BMedSci, MBBS, PhD, Blantyre, Malawi 8:40 The Role of Multicomponent Interventions for Chronic Respiratory Disease Prevention and Management in Low- and Middle-Income Countries. C. Jenkins, MD, Sydney, Australia 9:00 Infections and Lung Development: the Link Between Communicable and Non-Communicable Lung Disease H. Zar, MD, PhD, ATSF, Cape Town, South Africa 9:20 Panel Discussion W. Checkley, MD, PhD, Baltimore, MD

BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 1.5

D6 OBESITY-RELATED ASTHMA: MECHANISTIC STUDIES BEGIN TO INFORM THERAPEUTICS Assemblies on Allergy, Immunology and Inflammation; Respiratory Structure and Function 8:00 AM - 9:30 AM

Marriott Marquis Washington Independence Ballroom Salons E-H (Level M4)

ATS 2023 • Washington, DC