Final-Program-ATS-2023-AP.vp

WEDNESDAY • MAY 24

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• gain an understanding of the link between early-life exposures and asthma development • understand the integrated role of environmental exposures and multi-omics in incident asthma Growing evidence suggests that early-life environmental exposures (e.g., airway infection, nutrition, air pollution) contribute to the risk of developing asthma in childhood and beyond. During early-life development, environmental exposures interact with both the expression and function of human genetic/epigenetic factors and lead to differential disease risks. This session will highlight examples of recent studies from the NIH-supported Environmental Influences on Child Health Outcomes (ECHO) Program that offer deeper insights into the integrated roles of early-life environmental exposures, genetics, and epigenetics in incident asthma and the development of primary prevention strategies for asthma providers. Chairing: C.J. Blaisdell, MD, MEd, North Bethesda, MD K. Hasegawa, MD, MPH, PhD, Boston, MA 12:00 DNA Methylation Signatures of Early Life Exposures and Genetic Variation as Mediators of Asthma and Allergies in Childhood C. Ober, PhD, Chicago, IL 12:21 Vitamin C Supplementation to Maternal Smokers During Pregnancy: Stable Effects on Offspring Wheeze and Buccal DNA Methylation Through 5 Years of Age L. Shorey-Kendrick, PhD, BA, Beaverton, OR 12:42 Viral Bronchiolitis, Nasal Airway MicroRNA, and Risk for Developing Asthma Z. Zhu, ScD, Boston, MA 1:03 Integrative Metabolomics and the Early Life Origins of Asthma R.S. Kelly, MPH, PhD, Boston, MA 1:24 Patient Speaker L. Johnson-Law, Washington, D.C. BASIC • BEHAVIORAL • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 1.5 HUMANS, ANIMALS, THE ENVIRONMENT: WHY IS THE ONE HEALTH APPROACH NEEDED FOR EMERGING HEALTH ISSUES? Assemblies on Environmental, Occupational and Population Health; Allergy, Immunology and Inflammation; Behavioral Science and Health Services Research; Nursing; Pulmonary Infections and Tuberculosis 12:00 PM - 1:30 PM Walter E. Washington Convention Center Room 150 A-B (Street Level) D86

to reduce heterogeneity in clinical trial populations and individualize treatment protocols are central to efforts to improve outcomes. In this session we discuss both established and novel techniques for phenotyping critically ill patients with the aim of familiarizing clinicians, clinical researchers and basic researchers with the latest in the field. Chairing: C.C. Hardin, MD, PhD, ATSF, Boston, MA P. Sinha, MB BCh, PhD, ST LOUIS, MO T.K. Jones, MD, MPH, MSCE, Philadelphia, PA 12:00 Untangling Complexity in Critical Illness C.C. Hardin, MD, PhD, ATSF, Boston, MA 12:15 It’s Written in the Genes: Understanding the Susceptibilities to Critical Illness T.K. Jones, MD, MPH, MSCE, Philadelphia, PA 12:30 Polygenic Risk Scores in Critical Care: A Tale of Two Post-Operative Complications L. Bastarache, MS, Nashville, TN 12:45 Phenotypes in ICU Acquired Weakness C.C. Dos Santos, MD, Toronto, Canada 1:00 Phenotypes Over Clinical Syndromes: A More Logical Lumping Paradigm P. Sinha, MB BCh, PhD, ST LOUIS, MO 1:15 Clinical Trials and Treatment Effects: Don’t be Average, Be an Individual M.M. Churpek, MD, MPH, PhD, ATSF, Madison, WI D85 EARLY LIFE ENVIRONMENTAL EXPOSURES, EPIGENETICS, AND ASTHMA DEVELOPMENT Assemblies on Pediatrics; Allergy, Immunology and Inflammation; Environmental, Occupational and Population Health; Respiratory Cell and Molecular Biology 12:00 PM - 1:30 PM Walter E. Washington Convention Center Room 152 A-B (Street Level) Target Audience Researchers in asthma/allergy, genetics, epigenetics, virology, and bioinformatics, as well as clinicians/nurses/RTs/advanced practice providers who treat asthma Objectives At the conclusion of this session, the participant will be able to: • understand the potential and limitations of genetics, epigenetics, and integrated omics approaches in examining asthma pathogenesis BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 1.5

ATS 2023 • Washington, DC