Final-Program-ATS-2023-AP.vp

WEDNESDAY • MAY 24

335

12:54 Lipid Metabolism in Lung Diseases R. Summer, MD, Philadelphia, PA 1:12 Macrophage Metabolism in ARDS W.J. Janssen, MD, Denver, CO

BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 1.5

D88 BEYOND BIOENERGETICS: CELLULAR METABOLISM IN LUNG HEALTH AND DISEASE Assemblies on Respiratory Cell and Molecular Biology; Critical Care; Pulmonary Circulation; Pulmonary Infections and Tuberculosis; Respiratory Structure and Function; Thoracic Oncology 12:00 PM - 1:30 PM Marriott Marquis Washington Independence Ballroom Salons E-H (Level M4) Target Audience Basic and translational researchers, and clinicians who are interested in the mechanisms behind lung diseases Objectives At the conclusion of this session, the participant will be able to: • describe metabolic changes that occur in various cell populations in lung diseases and lung cancer • describe the role of mitochondria as signaling organelles in lung cancer • recognize disease specific metabolic changes in lungs cell and describe how metabolic pathways may potentially be targeted for treatment Cellular metabolism is the fundamental step of bioenergetic process. Growing evidence demonstrates the importance of cellular metabolism in disease pathogenesis beyond energy production. In this session, we will provide key knowledge about major cellular metabolic pathways and present recent discoveries and future perspectives on how these pathways regulate the pathogenesis of pulmonary diseases, such as COPD, pulmonary hypertension, interstitial lung diseases and lung cancer and how they may be targeted to alter disease progression. This session brings together experts who are among the pioneers to explore the new paradigm of cellular metabolic dysregulation as a key manifestation of pulmonary diseases. Chairing: G.M. Mutlu, MD, ATSF, Chicago, IL S.C. Erzurum, MD, Cleveland, OH G. Liu, MD, PhD, Birmingham, AL 12:00 Metabolic Changes in Immune Cells in COPD S.M. Cloonan, PhD, Dublin, Ireland 12:18 Amino Acid Metabolism in Pulmonary Fibrosis R.B. Hamanaka, PhD, Chicago, IL 12:36 Metabolism in Pulmonary Hypertension S.C. Erzurum, MD, Cleveland, OH

BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 1.5

D89 OSA-ASSOCIATED INFLAMMATION AND COMORBIDITIES: CAUSES AND CONSEQUENCES Assemblies on Sleep and Respiratory Neurobiology; Allergy, Immunology and Inflammation 12:00 PM - 1:30 PM Walter E. Washington Convention Center Room 207 A-B (Level 2) Target Audience Pulmonary critical care and sleep medicine practitioners (physicians, psychologists, nurse-practitioners) and researchers interested in the interactions between obstructive sleep apnea (OSA), inflammation, and comorbid chronic disease. Objectives At the conclusion of this session, the participant will be able to: • describe the interplay of both biologic (genetic) and epidemiologic associations between OSA, chronic systemic inflammation and comorbid disease.this will improve medical knowledge and practice-based learning and improvement • understand the contribution of OSA in chronic comorbid diseases, including asthma, interstitial lung disease, cardiovascular disease, and HIV. This will improve medical knowledge, practice-based learning and improvement, and evidence-based practice • identify research goals for precision health and personalized medicine in patients with OSA and co-morbid chronic inflammatory disease. This will improve medical knowledge This session will focus on the interplay between OSA-associated inflammation and chronic comorbidities. The session will begin by detailing both epidemiologic and genetic associations between OSA and inflammatory biomarkers, which are key mediators in the downstream cardiopulmonary consequences in OSA. Particular focus will be given to the contribution of OSA-associated inflammation in the acceleration of chronic comorbid diseases, including asthma, interstitial lung disease, cardiovascular disease, and HIV. The session will conclude with a discussion/Q&A that will explore future research areas for this important field. Chairing: V. Kundel, MD, New York, NY P.V. Borker, MD, Pittsburgh, PA B.E. Cade, PhD, Boston, MA

ATS 2023 • Washington, DC