Final-Program-ATS-2023-AP.vp

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WEDNESDAY • MAY 24

906 C/EBP Homologous Protein (CHOP) Is a Key Regulator of Lung Fibrosis in Alveolar Epithelial Type II (AT2)-specific Grp78 Knockout (KO) Mice/ W. Chen, Los Angeles, CA 907 Deletion of Alveolar Epithelial Type 1 Cell-specific Epithelial Membrane Protein 2 Protects From Lung Fibrosis/ W. Lopez Perez, Research Triangle Park, NC 908 ER Stress Induced PERK-Mediated Metabolic Reprogramming in Pulmonary Fibrosis/ J. Pandey, Birmingham, AL 909 TIMP-3 Expression Is Dysregulated by the Gain-of-Function MUC5B IPF Risk Variant/ J.S. Kurche, Aurora, CO 910 Dysfunctional Alveolar Repair and Pro-fibrotic Remodeling in Lymphangioleiomyomatosis (LAM)/ K. Obraztsova, Philadelphia, PA 911 Progression of Silica-induced Pulmonary Fibrosis Is Arrested After Selective Ablation of Col1a1+ Fibroblasts/ D. Foster, Denver, CO 912 A Brg1/PRMT5 Nuclear Complex Epigenetically Regulates the FOXO1 Transcription Factor in IPF Mesenchymal Progenitor Cells Promoting Self Renewal/ A. Jbeli, Minneapolis, MN 913 Prostaglandin F2 a Signaling, a Novel Modulator of Adventitial Fibroblasts in a Preclinical Mouse Model of Idiopathic Pulmonary Fibrosis/ L.R. Rodriguez, Philadelphia, PA 914 Profibrotic Fibroblasts Persist and Reactivate/ C. Molina, San Francisco, CA 915 Macropinocytosis Contributes to Profibrotic Responses of Lung Fibroblasts/ K. Tsoyi, Houston, TX 916 Discoidin Domain Receptor 2 Signaling Through PIK3C2 a Regulates Fibrosis/ K.K. Kim, Ann Arbor, MI 917 Ongoing Recruitment of Monocyte-derived Macrophages Is Necessary for the Maintenance of Chronic Pulmonary Fibrosis/ K. Kase, Kanazawa, Japan 918 Classical Monocytes Mediate Air Pollution Induced Acute Exacerbations of Pulmonary Fibrosis/ J.L. Larson-Casey, Birmingham, AL 919 Impaired Natural Killer Cell Function in the Lungs of Patients With Idiopathic Pulmonary Fibrosis/ P.A. Agudelo Garcia, Columbus, OH 920 Targeting STAT3 in the Vascular Endothelium/ B.J. Moss, Houston, TX 921 Expansion of Lung COL15A1+ Systemic Vasculature Is a Generalized Finding in Progressive Fibrotic Interstitial Lung Diseases/ E. Engelbrecht, Louisville, KY

120 Targeting IL-1beta to Diminish Age-associated Chronic Lung Sequelae Following Respiratory Viral Infection/ I.S. Cheon, Charlottesville, VA 121 Surfactant Protein A Alters Endosomal Trafficking and Susceptibility to Influenza A Virus in Macrophages/ Z.C. Chroneos, Hershey, PA 122 The Role of Type I IFN and IL-27 in Murine Betacoronavirus Infection/ M. Worley, Ann Arbor, MI 123 Glutamine Enhances Influenza A Virus Replication in Tissue-resident Alveolar Macrophages But Not in Bone Marrow-derived Macrophages/ O.R. Shamaa, Chicago, IL Metapneumovirus Infection in Human Airway Epithelial Cells/ I.A. Daniels, Indianapolis, IN 125 Interferon Regulatory Factor 3 Is Activated in Lung Epithelial Cells Following Pam2/ODN Treatment/ M.K. Longmire, Houston, TX D108 CELLS, SIGNALING, AND MEDIATORS IN LUNG REMODELING AND FIBROSIS 12:00 p.m. - 2:00 p.m. Marriott Marquis Washington Marquis Ballroom, Salons 3-4 (Level M2) Poster Viewing 12:00-12:45 Discussion 12:45-2:00 Chairing: M. Lehmann, PhD, Neuherberg, Germany M.N. Ballinger, PhD, ATSF, Columbus, OH T.S. Blackwell, MD, Nashville, TN 901 Epithelial Yap-Taz Deletion Promotes Maladaptive Alveolar Repair/ J.J. Gokey, Nashville, TN 902 Directed Differentiation of Alveolar Basal Cells Towards Surfactant Protein B Expressing Cells/ P. Khan, Basel, Switzerland 903 G-coupled Protein 87 (GPR87) a Cell Surface Orphan Receptor Expressed in Aberrant Basaloid Cells in IPF Mediates LPA Induced Fibrotic Gene Expression in Human iPSC Derived Basal Cells/ J. Khoury, New Haven, CT 904 Dysregulation of FOXN4+ Cells in the Small Airway Epithelium of Interstitial Lung Disease/ Y. Strulovici-Barel, New York, NY 905 A Novel Role for Primary Cilia in Fibrotic Lung Disease/ C. Trempus, Research Triangle Park, NC 124 The Effects of pH Alteration on Human BASIC • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION

ATS 2023 • Washington, DC