ATS 2024 Final Program

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120

MONDAY • MAY 20

research in pulmonary vascular biology as well as clinicians treating patients with pulmonary hypertension. Objectives At the conclusion of this session, the participant will be able to: • apply a broad understanding of newer unbiased analytic approaches to research ideas, even within the context of traditional hypothesis-driven research, and understand how to best leverage each frame in order to further discovery • describe new multi-omics findings in PH, including the discovery of emergent endophenotypes, and understand their relevance in the context of known, classical pathobiologic pathways and traditional disease classification frameworks • describe new 2022 ESC/ERS guidelines regarding modern imaging methods (e.g. use of CMR, TAPSE/PASP) and understand how precision imaging augments our understanding of disease pathobiology and may aid in predicting patient outcomes This session will pair senior investigators with junior investigators in the field of vascular biology, pulmonary hypertension and right heart failure in a pro/con debate of the research directions, disease paradigms, and treatment approaches over the past 40 years. The ideas covered will span basic, translational, and clinical topics. 9:15 Unbiased Approaches to Multi-Omic Datasets Can Unravel PAH Pathobiology 9:27 A Priori Hypothesis Generation and Reductionist Biology Decipher Mechanisms 9:39 Discussion 9:45 PAH Endo-Phenotypes and Tailored Treatments: One Drug for One Patient 9:57 Don’t Mistake the Forest for the Trees: One Drug for All 10:09 Discussion 10:15 Novel Imaging Approaches for Understanding Disease Pathogenesis and Predicting Clinical Outcomes 10:27 Tried and True: Simplicity is the Ultimate Sophistication Amidst Complexity 10:39 Discussion This session and the International Conference are supported

• contrast the strengths and limitations of observational and experimental evidence for SDB treatment’s impact on cardiovascular disease, including generalizability and sample diversity Randomized clinical trials (RCTs) have been the primary approach to causal inference in medicine. However, RCTs often include highly selected populations, limiting generalizability. Newer observational methodologies offer alternatives to analyze the efficacy of treatments using representative cohorts. However, these observational approaches can be limited by biases including the healthy adherer effect. Recently, RCTs and observational studies have had disparate findings around the efficacy of treatments for sleep-disorder breathing (SDB) on cardiovascular outcomes. These discrepancies will be debated during this session, examining the strengths and pitfalls from both sides. Finally, panelists will discuss the insights of these studies for future research. 9:15 Patient Speaker 9:20 Tools and Keys to Examining Causal Inference 9:31 “Does OSA Treatment Provide Cardiovascular Benefit?” Answers from RCTs 9:42 “Does OSA Treatment Provide Cardiovascular Benefit?” Answers from Real Life Data 9:53 “Should We Treat Central Sleep Apnea in Chronic Heart Failure Patients?” Answers from RCTs 10:04 “Should We Treat Central Sleep Apnea in Patients with Chronic Heart Failure ?” Answers from Real Life Data 10:15 Panel Discussion: “How Do We Derive Valid Inferences That Represent Our Large and Diverse Population?”

BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM

B7 PATHOGENIC CONCEPTS IN PAH

REVISITED? A MULTIGENERATIONAL PERSPECTIVE

Assembly on Pulmonary Circulation 9:15 a.m. - 10:45 a.m.

Marriott Marquis San Diego Marina Pacific Ballroom 21-22 (Ground Floor, North Tower)

by independent medical educational grants from Johnson&Johnson andMerck&Co., Inc.

Target Audience Physician-scientists conducting basic, translational and clinical

All CMEsessions have been planned and implemented in accordancewith the AccreditationCriteria of theAccreditationCouncil for ContinuingMedical Education (ACCME ® ) and are free of the control of ineligible companies (formerly commercial interests).

ATS 2024 Conference Program • San Diego, CA