ATS 2024 Final Program

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SUNDAY • MAY 19

85

P552 Repositioning of Basimglurant (mGluR5 Antagonist) for the Treatment of Idiopathic Pulmonary Fibrosis P553 PGK1 Mediates Deficient Pyruvate Utilization and Bioenergetic Compromise in Lung Fibroblasts in Age-related Lung Fibrosis P554 M2 Form of Pyruvate Kinase in Stiffness Induced Myofibroblast Differentiation in Lung Fibrosis P555 Sphingosine-1-phosphate Receptor 3 Induces Endothelial Mitochondrial Dysfunction in Ventilator-induced Lung Injury P556 Upregulation of Glutathione S Transferase P in Lung Epithelial Cells Augmentsinterleukin 1 Beta (IL1B)-induced Pro-inflammatory Signaling in Association With Oxidation of Ovarian Tumor Deubiquitinase 1 (OTUB1); Implications of Aberrant Epithelial Cells in P557 The Effect of S100A3 and S100A13 Mutations on the Expression of Mitochondrial Proteins in Atypical Pulmonary Fibrosis P558 Inhibition of Serine Glycine One Carbon Metabolism Attenuates Pulmonary Fibrosis in Mice P559 Mitochondrial one Carbon Metabolism Regulates RNA Methylation in Human Lung Fibroblasts P560 Loss of Glutaminase in Alveolar Macrophages Enhances Type I Interferon Response In Vitro and Improves Mortality During Influenza A Infection P561 Fumarate Metabolism Is an Unexpected Factor in the Success of Staphylococcus Aureus as a Pulmonary Pathogen P562 Treprostinil Palmitil Conversion Sites in the Lung P563 A Step Towards Precision Medicine: Using the Ratio Between Sphinoglipid and Steroid Metabolites as a Predictor or Asthma Exacerbations P564 LPCAT1 Protects the Functions of Alveolar Type II Cells by Modulating Lipid Metabolism P565 Fibroblast Specific Shh Regulate Lung Macrophage Phenotype and Metabolic Reprogramming P566 Comparing the Effects of Oxidised and Non-oxidised Lipids on Fibrogenesis in IPF P567 The Role of Resident Alveolar Macrophage Lipid Homeostasis in Pulmonary Fibrosis

P568 Unveiling Mitochondrial Changes and Metabolic Pathways in Fibroblasts From Patients With Idiopathic Pulmonary Fibrosis Under Hypoxic Stress P569 Reduced Epithelial NUPR1 Negatively Impacts Mitochondrial Function and Metabolism, and Increases Susceptibility to Emphysema

CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION

A75 REVISITING CURRENT METHODS IN PULMONARY FUNCTION TESTING 9:15 a.m. - 4:15 p.m. Viewing: Posters will be on display for entire session Discussion: 11:30-12:30 Discussionwith facilitators, authors, andattendees 12:30-1:15 Authorswill beby their posters for individual discussionwithattendees P571 Hidden Obesity and Preserved Ratio Impaired Spirometry in Subjects Participating Health Checkup Program P572 Preoperative Physiologic Pulmonary Evaluation Before Lung Resection: Impacts of Using the New Global Lung Function Initiative (GLI) Reference Values P573 COMPAIR: A Comparison of Clinic-based Versus Home-based Coached Spirometry P574 Time-Series Machine Learning Model Classifies Lung Function Using Spirometry Flow-Volume Loops Alone P575 Differentiation of Airways Disease From Mass-loading in Obese Patients Utilizing BMI-adjusted Normative Oscillometric Values P576 Aerosol Generation Using Different Delivery Methods During Simulated Bronchodilator Challenge Testing in the Pulmonary Function Laboratory P577 Preserved Ratio Impaired Spirometry in the Ugandan Link Cohort: A Longitudinal Follow Up San Diego Convention Center Area E (Hall A-B2, Ground Level)

ATS 2024 Conference Program • San Diego, CA