Final-Program-ATS-2023-AP.vp

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SUNDAY • MAY 21

917 Severity and Heterogeneity of Emphysema as Predictors of Success in Bronchoscopic Lung Volume Reduction/ J.S. Kim, Philadelphia, PA 918 Effect of Total Lung Capacity on the Pulmonary Vasculature in COPD Patients/ W. Dierckx, Kontich, Belgium 919 Factors Contributing to Exercise Induced CO2 Retention in COPD Patients/ W. Dierckx, Kontich, Belgium 920 Topological CT Analyses of Interstitial Lung Abnormalities in Chronic Obstructive Pulmonary Disease (COPD) Patients and Non-COPD Subjects Using Persistent Homology/ Y. Shiraishi, Kyoto, Japan 921 Assessment of Ventilation Heterogeneity in COPD Using Subsegmental Quantification With Single Photon Emission Computed Tomography/ M. Dalzell, Miami, FL BASIC • CLINICAL • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION A109 MICE TO HUMANS: MECHANISTIC DISCOVERIES IN SLEEP APNEA 2:15 p.m. - 4:15 p.m. Walter E. Washington Convention Center Room 144 A-C (Street Level) V.Y. Polotsky, MD, PhD, Baltimore, MD A. Laposky, PhD, Bethesda, MD R. Cortese, PhD, Columbia, MO 301 The Association Between Obstructive Sleep Apnea, Circulating Cytokines, and Incident Cancer/ A.M. Hirsch Allen, Vancouver, Canada 302 Senolytic Adjuvant Treatment Improves Metabolic Function in a Murine Model of Obstructive Sleep Apnea/ A. Khalyfa, Columbia, MO 303 Pinocembrin Ameliorates Intermittent Hypoxia-induced Neuroinflammation Through BNIP3-dependent Mitophagy in a Murine Model of Sleep Apnea/ L. Gong, Chengdu, China 304 Epigenetic Signatures in Circulating DNA in Patients With Obstructive Sleep Apnea Predict Atherosclerosis and Response to CPAP/ R. Cortese, Columbia, MO 305 Senolytic Treatment Combined With Reduction of Viewing 2:15-3:00 3:00-4:15 Summaries/Discussion Chairing: P.V. Borker, MD, Pittsburgh, PA

903 Linking Pathophysiology to Lung Pathology in Spiromics Using Respiratory Oscillometry (OSC) and High-resolution Computed Tomography (HRCT)/ C.B. Cooper, Los Angeles, CA 904 Relationships Between Clock Gene Expression and Inflammation in Bronchial Brushes of Severe COPD Patients/ X. Li, Groningen, Netherlands 905 Pathobiology of Airway and Arterial Vascular Remodeling in Chronic Obstructive Pulmonary Disease/ K. Wu, Vancouver, Canada 906 Proteomics of COPD-Related Phenotypes in the General Population. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study/ D.E. Guzman, New York, NY 907 Multiscale Stiffness of Emphysematous Human Precision-cut Lung Slices/ R. Krishnan, Boston, MA 908 Automated Measures of Airway-Artery Ratios Across Different GOLD Classes: A COPDGene Pilot Study/ H.A. Tiddens, Rotterdam, Netherlands 909 The Effect of Extra Fine Medium-dose Inhaled Corticosteroid/Long-Acting Beta-2 Agonist/Long-Acting Muscarinic Antagonist (ICS/LABA/LAMA) on Distal Airway Indices Using Functional Respiratory Imaging in Patients With Symptomatic COPD on ICS/LABA/ B.R. Lavon, Kontich, Belgium 910 Circadian Clock Signaling Regulates Pulmonary Microvascular Endothelial Repair in Response to Cigarette Smoke and Air Pollution/ X. Wu, Groningen, Netherlands 911 Sweat and Serum CRP Concentration in Humans With and Without Chronic Obstructive Pulmonary Disease: Implications for Wearable Biosensors/ J. Moore, Torrance, CA 912 Extracellular Vesicles and Soluble Factors Secreted by Lung Fibroblasts Have a Protective Effect on Elastase-induced Emphysema in Precision-cut Lung Slices/ L. Van Der Koog, Groningen, Netherlands 913 Identifying Responder Subgroups for Exacerbations Using Machine Learning in the Impact Trial/ K. Verstraete, Leuven, Belgium 914 Assessment of Regional Lung Ventilation Using Computer Tomography (CT) Lung Ventilation Analysis in Chronic Obstructive Pulmonary Disease (COPD)/ D. Karmali, Miami, FL 915 Analysis of Lung Shape Improves Quantitative Computed

Tomography Assessments of Chronic Obstructive Pulmonary Disease/ S.M. Humphries, Denver, CO

Intermittent Hypoxia (IH) Exposure Duration Mimicking “Good” CPAP Adherence Improves Coronary Artery Function in a Murine Model of OSA/ M. Badran, Columbia, MO

916 Changes in Lung Function With Diaphragm

Morphometry Following Bronchoscopic Lung Volume Reduction in Advanced Emphysema and Severe Hyperinflation/ J.S. Kim, Philadelphia, PA

ATS 2023 • Washington, DC